Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002803
Title: Inflammatory biomarkers in oral submucous fibrosis patients
Category: Pharmacology
Section: Research Article
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    Aim: The aim of the current study is to find the correlation between tumor necrosis factor-alpha (TNF-α) and C-reactive protein (CRP) levels and their expressions in oral submucous fibrosis (OSMF) patients and to develop a cheaper and effective biomarker for evaluation of this condition. Materials and Methods: Venous blood was collected from 60 healthy and OSMF diagnosed individuals; venous blood was collected from the participants and blood was distributed in the plain collection tube and centrifuged in 2500 rpm for 10 min. The serum was separated and analyzed for CRP by Turbilatex method using ERBA CHEM 5 plus analyzer. Moreover, then TNFα was analyzed by standard enzyme-linked immune-sorbent assay technology (ELISA) method using ROBONIK ELISA reader. Results: There was an elevation in TNF-alpha and CRP in OSMF patients where the mean TNF-alpha of normal patients are 2.06 ± 0.86, and OSMF patients had 4.76 ± 1.51. There was a statistically significant difference where P < 0.001 and the CRP of normal individuals is 2.96 ± 1.14 whereas CRP of OSMF patients was 9.87 ± 3.84. Conclusion: TNF-alpha and CRP are two inflammatory mediators which prove to be efficient biomarkers in the diagnosis of OSMF and in determining the prognosis of the patient by effective characterization and staging of the patient. These values can be interpreted at the bedside, with the full knowledge of all other clinical and pathological results.

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    Author(s) Name:

    Jembulingam Sabarathinam1 , G. Savitha2 *

    Affiliation(s) Name:

    1Department of Biochemistry, Saveetha Dental College, Saveetha University, Chennai, Tamil Nadu, India,

    2Department of Biochemistry, Saveetha Dental College, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: G. Savitha, Department of Biochemistry, Saveetha Dental College, Saveetha University, Chennai, Tamil Nadu, India

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    Jembulingam Sabarathinam1 , G. Savitha2 *

    Title:Inflammatory biomarkers in oral submucous fibrosis patients
    Journal:Drug Invention Today
    Vol(issue):10 (October [ Special Issue 2 ])
    Page No: (3022-3025)
  • Experimental Methods Keywords

    Methodology: Biomarkers, C-reactive protein, Inflammatory status, Oral submucous fibrosis, Tumor necrosis factor-alpha
    Research Materials:oral submucous fibrosis patients


Biomarkers C-reactive protein Inflammatory status Oral submucous fibrosis Tumor necrosis factor-alpha

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