Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002808
Title: Levothyroxine dosage requirement during pregnancy
Category: Pharmacology
Section: Research Article
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    Background and Objectives: Hypothyroidism is a common endocrine disease affecting up to 5% of the general population worldwide. The present study was aimed to determine the levothyroxine dose to treat hypothyroidism during pregnancy. Methods: It was a clinical trial study which had conducted on 90 pregnant women diagnosed with either subclinical (n = 45) or clinical or overt hypothyroidism (n = 45) referred to Imam Khomeini Hospital in Ahvaz city, Iran. At the beginning of the study, all subjects were measured weight least dressed condition, and then, LT4 dosage was calculated according to the patients’ weight in µg/kg. The mean daily LT4 dose was compared between the two groups of subclinical and overt hypothyroidism. The data were analyzed with the Statistical Package of the Social Sciences (version 19, Windows) using descriptive statistics and analytical tests (t-test and Mann–Whitney). For all statistical tests, the level of 0.05 was considered as statistically significant. Results: The results showed that the mean daily LT4 dose in the overt and subclinical hypothyroidism was, respectively, 2.69 ± 1.78 and 2.17 ± 1.60 µg/kg, indicating statistically significant difference between the two groups (t=−8.662 and P = <0.001). Conclusion: For efficient treatment of hypothyroidism, it is recommended to use appropriate dosage of LT4 according to the stage of the hypothyroidism where subclinical stage needs lower dosage.

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    Author(s) Name:

    Seyedbahman Ghaderian, Homeira Rashidi, Sedigheh Etessaminia*

    Affiliation(s) Name:

    Department of Internal Medicine, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    *Corresponding author: Sedigheh Etessaminia, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

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    Seyedbahman Ghaderian, Homeira Rashidi, Sedigheh Etessaminia*

    Title:Levothyroxine dosage requirement during pregnancy
    Journal:Drug Invention Today
    Vol(issue):10 (October [ Special Issue 2 ])
    Page No: (3046-3049)
  • Experimental Methods Keywords

    Methodology:a clinical trial study
    Research Materials:Levothyroxine dose


Hypothyroidism Levothyroxine dose Overt Pregnant women Subclinical

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