Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-Ph-0000282
Title: Hydrogel based biodegradable enteric coated alginate beads for colon targeted drug delivery of embelin
Category: Pharmaceutics
Section: Research Article
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    Alginate, a natural polysaccharide has been extensively used as a matrixing agent for number of allopathic drugs. In the present investigation attempt is made to develop a sustained release multi particulate dosage form containing herbal molecule. Embelin, a well-proven anthelmentic from herbal origin was formulated in to gel beads of sodium alginate. A 23 full factorial design has been adopted for optimization of cross-linked sodium alginate beads containing embelin. Sodium alginate (10% w/v) was used as a polymer. Based on preliminary studies, the constraints of independent variables X1 (concentration of cross linking agent), X2 (type of hardening agent) and X3 (drying temperature for beads) have been fixed. The dependent variable that has been selected was Y1 (time taken for 80% drug release from beads, T80). The application of factorial design gave systematic approach in optimization on formulation variables. Concentration of cross linking agent (10% and 20% CaCl2) and type of hardening agent (Isopropyl alcohol and Glutaraldehyde) were found to be effective in controlling the gel bead size and T80. The drug release was found to follow Korsmeyer model of diffusion. A USP dissolution guideline, similarity factor f2 for drug release from gel beads with and without colonic fluid showed dissimilarity in drug release pattern. Further, optimized gel beads were film coated with HPMC phthalate to prevent the early release of embelin in upper GI tract and allowing majority of drug to release in lower intestine.

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    Author(s) Name:

    Munira Momin*1, Tejal Mehta2, Pooja Abhang1

    Affiliation(s) Name:

    1 Oriental College of Pharmacy, Sector-2, Sanpada, Navi Mumbai 400705,India
    2 Nirma Institute of Pharmacy, Nirma University, Thaltej Highway, Ahmedabad 382481 Gujarat India

    *Corresponding author.
    Dr. Munira M Momin
    Professor,
    Oriental College of Pharmacy,
    Sector-2, Sanpada
    Navi Mumbai 400705,India


    Received on:17-12-2012; Revised on: 19-01-2013; Accepted on:10-02-2013

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    Author:

    Munira Momin*1, Tejal Mehta2, Pooja Abhang1

    Title: Hydrogel based biodegradable enteric coated alginate beads for colon targeted drug delivery of embelin
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (March)
    Year:2013
    Page No: (288-292)
  • Experimental Methods Keywords

    Methodology:colon targeted drug delivery
    Research Materials:embelin

Keywords

Biodegradable Cross-linked Alginate beads Embelin

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