Journal: Drug Invention Today

Article Id: JPRS-DFA-00002822
Title: Response surface methodology for optimization of simvastatin-loaded self-emulsifying drug delivery system
Category: Drug or Formulation Analysis
Section: Research Article
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    Objective: The objective of this research work was to formulate, optimize, and evaluate a self-emulsifying drug delivery system (SEDDS) of simvastatin (SIM) by employing a systematic formulation strategy using response surface methodology, i.e., Box–Behnken design (BBD) and to acquire basic concepts that assist in the evolution of such systems more practicable. Methods: Screening of oils and surfactants was done on the basis of solubility studies and phase diagrams were constructed to define the upper and lower limit of oil and surfactant for formulation development. BBD was applied involving three variables (concentration of oil, concentration of surfactant, and mixing time) and two responses (emulsification time and percentage transmittance). This approach aided in predicting the effect of individual component on the responses with the help of response surface curves and to investigate the interactions between excipients and thus to discover the best formulation. Results: Run order 3 was selected which was further validated using optimization of data. Finally, formulation OF1 was optimized and characterized for particle size, polydispersity index (PDI), zeta potential, emulsification time, percentage transmittance and in vitro dissolution studies. For OF1, the value of particle size, PDI, zeta potential, emulsification time, and percentage transmittance was 162 nm, 0.194, −22.3 mV, 93 s, and 99.45%, respectively. In vitro release studies from optimized formulation, OF1, displayed highest drug release as compared to SIM API and marketed preparation, thus enhancing the dissolution. Conclusion: This study confirms that for emergence of a successful SEDDS with enhancement in dissolution of a BCS Class II drug for oral administration can be more relevant by employing experimental design.

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    Author(s) Name:

    Madhu Verma1,2 *, Arun Nanda3 , Yatendra Kumar1

    Affiliation(s) Name:

    1 Department of Pharmaceutics, I.T.S College of Pharmacy Muradnagar, Ghaziabad, Uttar Pradesh, India,

    2 Faculty of Pharmacy, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India,

    3 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India

    *Corresponding author: Madhu Verma, I.T.S College of Pharmacy, Delhi-Meerut Road, Muradnagar, Ghaziabad - 201 206, Uttar Pradesh, India

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    Author:

    Madhu Verma1,2 *, Arun Nanda3 , Yatendra Kumar1

    Title:Response surface methodology for optimization of simvastatin-loaded self-emulsifying drug delivery system
    Journal:Drug Invention Today
    Vol(issue):10 (October [ Special Issue 2 ])
    Year:2018
    Page No: (3100-3106)
  • Experimental Methods Keywords

    Methodology:Box–Behnken design, Emulsification time and percentage transmittance, Response surface methodology, Self-emulsifying drug delivery system
    Research Materials:Simvastatin

Keywords

Box–Behnken design Emulsification time and percentage transmittance Response surface methodology Self-emulsifying drug delivery system Simvastatin

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