Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002825
Title: Grape seed extract as a potential remineralizing agent - A structured review
Category: Pharmacology
Section: Research Article
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    Background: Dental caries is the most common chronic disease of mankind. Dental caries development is considered to involve a triad of indispensable factors that can be concluded as bacteria in dental plaque, carbohydrates in the diet and susceptible teeth. Grape seed extract (GSE) is a rich source of proanthocyanidin (PA), mainly composed of monomeric catechin and epicatechin, gallic acid and polymeric, and oligomeric procyanidins. It verified that GSE, composed mainly of PA, can positively affect the tooth structure, thus offering a new therapy for carious lesions. Aim: The aim of this systematic review was to analyze the existing literature on the remineralizing effect of GSE on caries-like lesion compared to other remineralizing agent. Materials and Methods: Search strategy - The Data Bases of PubMed, Cochrane, Science direct, Lilacs, and Google Scholar were searched for the period from January 2000 to October 2017. References of selected articles and relevant reviews were searched for any missed publications. Selection criteria - a in vitro study evaluating the remineralizing potential of GSE on enamel, dentin, and root caries on human permanent, primary teeth, and bovine teeth. Results: The systematic search revealed a total of 340 publications from PubMed, Cochrane, Science direct, Lilacs, and Google Scholar. The articles were scrutinized based on present inclusion and exclusion criteria. 11 publications fulfilled all the inclusion criteria, and 329 publications were excluded from the review. Conclusion: With the available evidence, GSE was found to have remineralizing effect on dental caries. In the future, GSE with its antimicrobial, antigingivitis, and anticaries effect can be utilized in preventive and restorative materials to preserve the dental health.

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    Author(s) Name:

    Maheswari Elumalai, Meignana Arumugham Indiran, Pradeep Kumar Rathinavelu, Sri Sakthi Doraikannan*, Jayashri prabhakar

    Affiliation(s) Name:

    Department of Public Health Dentistry, Saveetha Dental College, Saveetha University, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India

    *Corresponding author: Sri Sakthi Doraikannan, Department of Public Health Dentistry, Saveetha Dental College, Saveetha University, Saveetha Institute of Medical and Technical Sciences, Chennai, 162, Poonamallee High Road, Velappanchavadi, Thiruverkadu, Chennai – 600 077, Tamil Nadu, India.

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    Author:

    Maheswari Elumalai, Meignana Arumugham Indiran, Pradeep Kumar Rathinavelu, Sri Sakthi Doraikannan*, Jayashri prabhakar

    Title:Grape seed extract as a potential remineralizing agent - A structured review
    Journal:Drug Invention Today
    Vol(issue):10 (October [ Special Issue 2 ])
    Year:2018
    Page No: (3116-3128)
  • Experimental Methods Keywords

    Methodology:remineralizing agent,Artificial caries, Enamel caries, Knoop hardness
    Research Materials:Grape seed extract

Keywords

Artificial caries Enamel caries Knoop hardness Proanthocyanidins Remineralization

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