Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-PDRS-0000283
Title: Hepatoprotective effect of methanol seed extract of Sphenostylis stenocarpa (Hoschst ex. A. Rich, Harms) against carbon tetrachloride induced liver toxicity in wistar rats
Category: Plant Drugs Related Study
Section: Research Article
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    The present study was carried out to evaluate the effect of methanol seed extract of Sphenostylis stenocarpa (African yam bean) on some antioxidant and liver marker enzymes of rats treated with CCl4 as well as the acute toxicity test of the extract. Twenty four (24) Wistar rats were randomly distributed into 6 groups of 4 rats each. Group 1 rats were not induced with CCl4 and were given normal rat feed and water (normal control). Groups 2-6 were induced with CCl4. Group 2 rats received no treatment (negative control) and those in group 3 received 300 mg/kg body weight of ascorbic acid (standard drug). Groups 4, 5 and 6 were treated respectively with 200, 400 and 800 mg/kg body weight of S. stenocarpa methanol seed extract. The acute toxicity test (LD50) of the extract showed no toxicity up to 5000 mg/kg body weight. This showed that the seed of the plant is safe for human and animal consumption. The glutathione concentration, catalase and superoxide dismutase activity of the rats increased significantly (p<0.05) in a dose dependent manner in all the treatment groups. The methanol seed extract had a positive effect on the antioxidant enzymes of rats treated with CCl4. There were no significant (p>0.05) increase in the alanine aminotransferase, Aspartate aminotransferase and alkaline phosphatase activity of rats in all the treatment groups. These suggest that S. stenocarpa seeds possess some antioxidant and non-hapatotoxic properties.

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    Author(s) Name:

    *Okonkwo1, Christopher C.,1 Njoku, Obioma U., 1Ikevude, Chizaramoku T. and 1Odo, Christian E.

    Affiliation(s) Name:

    1 Lipids and Lipoprotein Research Unit, Department of Biochemistry, University of Nigeria, Nsukka

     

    *Corresponding author.
    Okonkwo, Christopher C
    Lipids and Lipoprotein Research Unit, Department of Biochemistry,
    University of Nigeria, Nsukka

    Received on:17-12-2012; Revised on: 19-01-2013; Accepted on:10-02-2013

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    Author:

    *Okonkwo1, Christopher C.,1 Njoku, Obioma U., 1Ikevude, Chizaramoku T. and 1Odo, Christian E.

    Title:Hepatoprotective effect of methanol seed extract of Sphenostylis stenocarpa (Hoschst ex. A. Rich, Harms) against carbon tetrachloride induced liver toxicity in wistar rats
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (March)
    Year:2013
    Page No: (293-298)
  • Experimental Methods Keywords

    Methodology:catalase, hepatotoxicity
    Research Materials:Sphenostylis stenocarpa

Keywords

Sphenostylis stenocarpa carbon tetrachloride catalase hepatotoxicity

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