Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002836
Title: New phenomena in the clinical and morphological aspects of osteoporosis
Category: Pharmacology
Section: Research Article
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    Objective: The aim of this study is to compare the biochemical indexes of phosphorus-calcium (Ca) metabolism in patients with metabolic syndrome of 1–5 stages, associated with osteoporosis with morphological picture of bone tissue. Materials and Methods: A total of 248 patients (99 men and 149 women) in the age from 60 to 69 (mean age was 64 ± 3.5) were examined during the study. Results: The results of the study of biochemical indexes of phosphorus-calcium (Ca) metabolism in patients with metabolic syndrome associated with osteoporosis were presented in the article. The clinical picture is compared with electronic microscopically features of bone tissue and indexes of elements in it. It was shown that phosphorus- Ca imbalance in patients with metabolic syndrome has already determined on the 2nd stage of the metabolic syndrome and it is represented by decreasing of 1.25 (OH)2 Vitamin D and increasing of parathyroid hormone in blood serum, what is associated with beginning of osteoporosis. Conclusion: Bone mineral density is decreased in patients with metabolic syndrome of 1–4 stages as metabolic syndrome progresses. Osteoporosis/osteopenia is more expressed in bones of the forearm, and it is connected with hyperparathyroidism in patients with metabolic syndrome of the 5th stage.

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    Author(s) Name:

    Tatyana V. Pavlova*, Ilya P. Bashuk, Natalia B. Pilkevich, Liubov A. Pavlova

    Affiliation(s) Name:

    Department of Pathology, Belgorod State University, Pobedy str., 85, 308015, Belgorod, Russian Federation, Russia

    *Corresponding author: Tatyana V. Pavlova, Department of Pathology, Belgorod State University, Pobedy Str., 85, 308015, Belgorod, Russian Federation, Russia.

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    Author:

    Tatyana V. Pavlova*, Ilya P. Bashuk, Natalia B. Pilkevich, Liubov A. Pavlova

    Title:New phenomena in the clinical and morphological aspects of osteoporosis
    Journal:Drug Invention Today
    Vol(issue):10 (November [ Special Issue 3 ])
    Year:2018
    Page No: (3176-3179)
  • Experimental Methods Keywords

    Methodology:Bone mineral density, Osteoporosis, Phosphorus-calcium metabolism
    Research Materials:248 patients (99 men and 149 women)

Keywords

Bone mineral density Osteoporosis Phosphorus-calcium metabolism

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