Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002840
Title: Regulation mechanism of heartbeat rate, shocked blood volume, and their formation heterochronousity among small laboratory animals
Category: Pharmacology
Section: Research Article
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    Objective: The purpose of this study was to study the peculiarities of HR, SVB, and the mechanisms of their regulation development among rats from the 1st day of life and up to the age of 70 days. Methods: The method of tetrapolar thoracic rheography was used to determine the HR and shock volume of blood (SVB). The principle of impedance electroplethysmography method is to record the oscillations of the complex electrical resistance (impedance) of a bioobject for high-frequency current; the fluctuations of resistance are proportional to the changes in blood supply. Results: In experiments on white mongrel laboratory rats, it was established that from the 1st day of life to the age of 70 days, the periods of the greatest change in the heart rate of rats alternate with the stages of a significant increase in the shock volume of the blood. In the mechanisms of regulation of the shock volume of blood in rats, the sympathetic regulatory effect is manifested much earlier than the parasympathetic. Conclusion: However, in the future, their ratio changes somewhat: A more pronounced sympathetic regulatory effect on UCS persists up to 70 days of age, whereas from the 8-week-old age, the parasympathetic effect is significantly reduced.

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    Author(s) Name:

    B. I. Vakhitov1 *, I. Kh Vakhitov1 , A. H. Volkov2 , S. S. Chinkin2

    Affiliation(s) Name:

    1 Department of Veterinary Medicine, Kazan State Academy of Veterinary Medicine Named After N.E. Bauman, Kazan Federal University, Kazan 420008, Russia,

    2 Department of Veterinary Medicine, Kazan State Academy of Veterinary Medicine Named After N.E. Bauman, Sibirskiy Trakt 35, Kazan, Russia

    *Corresponding author: B. I. Vakhitov, Department of Veterinary Medicine, Kazan State Academy of Veterinary Medicine Named After N.E. Bauman, Kazan Federal University, 18 Kremlevskaya Street, Kazan 420008, Russia.

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    Author:

    B. I. Vakhitov1 *, I. Kh Vakhitov1 , A. H. Volkov2 , S. S. Chinkin2

    Title:Regulation mechanism of heartbeat rate, shocked blood volume, and their formation heterochronousity among small laboratory animals
    Journal:Drug Invention Today
    Vol(issue):10 (November [ Special Issue 3 ])
    Year:2018
    Page No: (3193-3196)
  • Experimental Methods Keywords

    Methodology: tetrapolar thoracic rheography
    Research Materials:rats

Keywords

Heart rate Heterochronicity M-cholinoblocker Stroke volume α-Blocker

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