Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-Pha-0000285
Title: Evaluation of Dregea volubilis leaf extract for its potential against stress induced amnesia in experimental rats
Category: Pharmacology
Section: Research Article
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    The world is focusing more upon the herbal medication for curing various ailments. The trend of validating the plants with traditional medicinal usage is increasing. The present investigation deals with the protective effect of Alcoholic extract of Dregea volubilis leaves (AEDV) against stress induced amnesia. In the present study the extract (250 and 500 mg/kg, p.o) was investigated for its Nootropic potential in normal and stress induced rats. The invitro antioxidant activity was carried out to correlate its protective affect against stress. Conditioned avoidance response using Cook’s pole climbing apparatus was used in normal and stress induced rats to assess cognitive-improving activities. The invitro antioxidant activity was carried out by reducing power assay. Daily administration of Dregea volubilis at doses of 300 and 500 mg/kg, p.o enhanced cognition in dose dependent manner in normal rats. Fast retrieval was observed in extract treated stress induced rats, compared to that of stress control group. In Ferrous reducing power assay significant increase in absorbance was observed with extract in dose dependent manner and the results were comparable with that of standard, Ascorbic acid. The present study justifies scientific support for the protective effect of Dregea volubilis against stress induced amnesia & useful in combating the stress induced CNS disorders.

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    Author(s) Name:

    Ch.Sandhya1*, K.Divya mohana, S.Sasmitha, P.V.N.S.Mounika, G.V.Sampath kumar2

    Affiliation(s) Name:

    1. Department of Pharmacology, VJ’S college of pharmacy, Rajahmundry, East Godavari District, Andhra Pradesh, India.
    2. Department of Pharmacology, A.U.College of Pharmaceutical Sciences, Andhra University, Visakhapatnam,Andhra Pradesh, India.

    *Corresponding author.
    Ch.Sandhya
    Department of Pharmacology,
    VJ’S college of pharmacy,
    Rajahmundry, East Godavari District,
    Andhra Pradesh, India

    Received on:17-01-2013; Revised on: 19-02-2013; Accepted on:26-02-2013

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    Author:

    Ch.Sandhya1*, K.Divya mohana, S.Sasmitha, P.V.N.S.Mounika, G.V.Sampath kumar2

    Title:Evaluation of Dregea volubilis leaf extract for its potential against stress induced amnesia in experimental rats
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (March)
    Year:2013
    Page No: (304-307)
  • Experimental Methods Keywords

    Methodology: Oxidative Stress, Cognition, Antioxidant
    Research Materials:Dregea volubilis

Keywords

Dregea volubilis Oxidative Stress Cognition Antioxidant

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