Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-Ph-0000286
Title: Novel Controlled Gastroretentive Drug Delivery Systems: A Review
Category: Pharmaceutics
Section: Review Article
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    Controlled release (CR) dosage forms have been extensively used to improve therapy with several important drugs. However, the development processes are faced with several physiological difficulties such as the inability to restrain and localize the system within the desired region of the gastrointestinal tract and the highly variable nature of the gastric emptying process. This variability may lead to unpredictable bioavailability and times to achieve peak plasma levels. On the other hand, incorporation of the drug in a controlled release gastroretentive dosage forms (CR-GRDF) which can remain in the gastric region for several hours would significantly prolong the gastric residence time of drugs and improve bioavailability, reduce drug waste, and enhance the solubility of drugs that are less soluble in high pH environment. Gastroretention would also facilitate local drug delivery to the stomach and proximal small intestine. Thus, gastroretention could help to provide greater availability of new products and consequently improved therapeutic activity and substantial benefits to patients. Controlled gastric retention of solid dosage form may be achieved by the mechanisms of floatation, mucoadhesion, sedimentation, expansion or by a modified shaped system. The purpose of this paper is to review the recent literature and current technology used in the development of gastroretentive dosage forms.

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  • About the authors and Affiliations

    Author(s) Name:

    V. D. Gaikwad *, V. D. Yadav and P. D. Jadhav

    Affiliation(s) Name:

    Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Jaitapur, Satara-415004, India

    *Corresponding author.
    V. D. Gaikwad
    Department of Pharmaceutics,
    Arvind Gavali College of Pharmacy,
    Jaitapur, Satara-415004, India


    Received on:11-01-2013; Revised on: 07-02-2013; Accepted on:25-02-2013

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    Author:

    V. D. Gaikwad *, V. D. Yadav and P. D. Jadhav

    Title:Novel Controlled Gastroretentive Drug Delivery Systems: A Review
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (March)
    Year:2013
    Page No: (308-315)
  • Experimental Methods Keywords

    Methodology:Narrow absorption window, Floating dosage form
    Research Materials:synthetic drugs

Keywords

Gastroretention Oral controlled release Swelling Narrow absorption window Floating dosage form

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