Journal: Drug Invention Today

Article Id: JPRS-PP-00002870
Title: Qualitative and quantitative phytochemical analysis and in vitro antioxidant activities of methanolic leaf extract of Rhizophora apiculata blume
Category: Pharmacognosy and Phytochemistry
Section: Research Article
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    Introduction: An oxidative stress results from the imbalance between the free radicals and the antioxidant system, and up regulated reactive oxygen and nitrogen species have been associated with oxidative stress diseases. Rhizophora apiculata Blume is an important medicinal plant long time used by many people in Asia and Africa continents for curing both the infectious and non-infectious diseases. Objective: The objective of the present study was to find the qualitative and quantitative phytochemical and evaluate the in vitro antioxidant activity of the methanolic leaf extract of R. apiculata Blume. Materials and Methods: The qualitative phytochemical analysis, quantitative estimations of total phenolic, alkaloid, flavonoid, tannin, and saponin content, and in vitro antioxidant activities (1,1-diphenyl-2-picrylhydrazyl [DPPH], hydrogen peroxide, superoxide, and hydroxy radical) of the methanolic leaf extract of R. apiculata Blume were performed using standard procedures. Results: The quantitative phytochemical analysis of the methanolic leaf extract of R. apiculata Blume revealed the presence of considerable amounts of tannins (95.14 µg/ml tannic acid equivalents/g), flavonoids (87.18 µg/ ml quercetin equivalents/g), phenolic compounds (54.56 µg/ml, gallic acid equivalents/g), saponins (4.17 µg/ml), and alkaloids (3.78 µg/ml), and further, the in vitro antioxidant activity of the ethanolic leaf extract of R. apiculata Blume showed significant scavenging activity on increasing order of H2 O2 > DPPH > OH > O2 compared to that of standard ascorbic acid. Conclusion: Based on the present results, the methanolic leaf extract of R. apiculata Blume contained high amount of flavonoid, tannin, and phenolic compounds, thereby existing significant in vitro antioxidant activity, and the ethanolic leaf extract of R. apiculata Blume can be used as a potential source of desired bioactive natural antioxidants for the development of therapeutic antioxidant drugs

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    Author(s) Name:

    M. Muthulingam1 *, K. Krishna Chaithanya2

    Affiliation(s) Name:

    1Department of Zoology, Faculty of Science, Annamalai University, Chidambaram, Tamil Nadu, India,

    2 Departments of Chemistry, College of Natural and Computational Sciences, Aksum University, Aksum, Ethiopia

    *Corresponding author: Dr. M. Muthulingam, Department of Zoology, Annamalai University, Annamalainagar, Chidambaram - 608 002, Tamil Nadu, India.

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    Author:

    M. Muthulingam1 *, K. Krishna Chaithanya2

    Title:Qualitative and quantitative phytochemical analysis and in vitro antioxidant activities of methanolic leaf extract of Rhizophora apiculata blume
    Journal:Drug Invention Today
    Vol(issue):10 (November [ Special Issue 3 ])
    Year:2018
    Page No: (3335-3343)
  • Experimental Methods Keywords

    Methodology:Antioxidants, Free radicals, Medicinal plant, Phytochemicals,
    Research Materials: Rhizophora apiculata Blume

Keywords

Antioxidants Free radicals Medicinal plant Phytochemicals Rhizophora apiculata Blume

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