Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002888
Title: Major weed Parthenium hysterophorus L. as a propitious plant with its free radical scavenging activity and anticancer activity against A549 lung cancer cell line
Category: Pharmacology
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Objective: The objective of this study was to investigate the antioxidant and anticancer activity of the Parthenium hysterophorus L. against A549 lung cancer cell line. Background: P. hysterophorus L. is a pernicious herb which is a weed with dominating nature in the productive crop field, by collecting minerals and water before the productive crop takes. P. hysterophorus L. belongs to the family of Asteraceae and grows energetically even in low water supply in all fields and gardens. Many recent research findings have shown that the weeds are having immense medicinal potency including anticancer activity. Materials and Methods: In this study, the methanolic extract of the leaves of P. hysterophorus L. was analyzed for the presence of various biological active phytochemicals through gas chromatography–mass spectrometry (GC-MS) analysis and its antioxidant activity. The P. hysterophorus L. was also analyzed for its anticancer activity against A549 cancer cell line. Outcome Measure: The P. hysterophorus L. weed which can be grown easily can be used for the human beneficial and the discovery of the new therapeutic drugs. Results: The GC-MS analysis has shown the presence of betahistine, hexadecanoic acid methyl ester, phytol, benzaldehyde, 4 (dimethylamino), pentadecanoic acid, 14-methyl-, and methyl ester which are biologically active compounds. The methanolic extract of the P. hysterophorus L. was tested for the free radical scavenging activity by doing 2,2-diphenyl-1-picrylhydrazyl assay and its inhibitory concentration (IC50) value was found to be 122.85 µg/ml. The anticancer activity was analyzed by the 3-(4,5-dimethyl-2-thiazolyl)2,5-diphenyl-2,4 tetrazolium bromide assay against A549 lung cancer cell line. An increase in cancer cell growth inhibition was observed with an increase in the concentration of the drug and its IC50 value is 73.74 µg/ml. Conclusion: From the study results, it is evident that the weed P. hysterophorus L. is a rich source of phytochemicals as shown by GC-MS report which can be used in different medication for the human welfare. This P. hysterophorus L. is found to have a good antioxidant property as well as a promising anticancer effect.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    Jagadish Kumar Suluvoy, Ebin Philip Thompson, V. M. Berlin Grace*

    Affiliation(s) Name:

    Department of Biosciences and Technology, Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu, India


    *Corresponding author: V. M. Berlin Grace, Department of Biosciences and Technology, Karunya Institute of Technology and Sciences, Coimbatore - 641 114, Tamil Nadu, India

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Jagadish Kumar Suluvoy, Ebin Philip Thompson, V. M. Berlin Grace*

    Title:Major weed Parthenium hysterophorus L. as a propitious plant with its free radical scavenging activity and anticancer activity against A549 lung cancer cell line
    Journal:Drug Invention Today
    Vol(issue):10 (November [ Special Issue 3 ])
    Year:2018
    Page No: (3424-3429)
  • Experimental Methods Keywords

    Methodology: gas chromatography–mass spectrometry (GC-MS) analysis
    Research Materials: Parthenium hysterophorus L.

Keywords

2 2-Diphenyl-1-picrylhydrazyl A549 Asteraceae Gas chromatography–mass spectrometry 3-(4 5-Dimethyl- 2-Thiazolyl)2 5-diphenyl-2 4 Tetrazolium Bromide Parthenium hysterophorus L.

Our Services

Most Downloaded List