Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002897
Title: Pharmacotherapy for the prevention of the progression of chronic heart failure in elderly patients with coronary heart disease
Category: Pharmacology
Section: Research Article
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    Aim: Chronic heart failure (CHF), which occurs as a result of common cardiovascular diseases in the elderly, combined with age-related changes in both structural and functional features of the heart. Myocardial remodeling is an essential substrate that determines the occurrence and progression of CHF in elderly patients. In all forms of left ventricular (LV) myocardial remodeling, there is a decrease in both LV diastolic relaxation and atrial filling. The object of our study was 140 elderly men suffering from CHF who had a myocardial infarction. Materials and Methods: The object of our study was 140 elderly men with CHF on the background of long-term chronic coronary artery disease who had suffered AMI, whose average age was 68.4 ± 7.8 years. Results: It was determined that the majority of elderly patients with coronary heart disease, post-infarction cardiosclerosis develops hypertrophic remodeling, while a smaller number of patients myocardial remodeling occurs by dilation type. In our study, the maximum reduction of diastolic relaxation was found in patients with eccentric hypertrophy, which is accompanied by the most significant drop in the ejection fraction (EF). Conclusion: With concentric hypertrophy of the left ventricle of the heart and concentric remodeling, the decrease in diastolic filling and atrial filling is accompanied by the preservation of the rate of circular shortening of fibers (CSF) and EF.

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    Author(s) Name:

    Olga A. Osipova1 , Nina I. Zhernakova2 , Andrey I. Golovin3 , Alfiya E. Pushkareva1 , Olga M. Godlevskaya4

    Affiliation(s) Name:

    1  Department of Hospital Therapy, Belgorod State University, Belgorod, Russia,

    2 Faculty of General Medicine and Pediatrics, Bashkortostan State Medical University, Ufa, Russia,

    3 Student of Medical Institute, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine,

    4 Kharkiv Medical Academy of Postgraduate Education, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine

    *Corresponding author: Olga A. Osipova, Belgorod State University, Belgorod, Russia.

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    Author:

    Olga A. Osipova1 , Nina I. Zhernakova2 , Andrey I. Golovin3 , Alfiya E. Pushkareva1 , Olga M. Godlevskaya4

    Title:Pharmacotherapy for the prevention of the progression of chronic heart failure in elderly patients with coronary heart disease
    Journal:Drug Invention Today
    Vol(issue):10 (December [ Special Issue 4 ])
    Year:2018
    Page No: (3456-3460)
  • Experimental Methods Keywords

    Methodology:, Post-infarction cardiosclerosis, Remodeling of myocardium of the left ventricle
    Research Materials:140 elderly men with CHF

Keywords

Chronic heart failure Ischemic heart disease Post-infarction cardiosclerosis Remodeling of myocardium of the left ventricle

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