Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002899
Title: Analysis of the influence of chronic heart failure type on changes in the microelement composition of myocardial tissue in patients of senile age
Category: Pharmacology
Section: Research Article
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    Aim: Conduct a comparative analysis of the content and distribution of macroelements (Ca2+, K+, Mg2+, and Na+) in myocardial tissue according to autopsy data in elder patients with CHF, depending on the LV EF. Materials and Methods: Methods of optical plasma emission spectrometry of parallel action with inductively coupled plasma-9000 and scanning electron microscopy (FEI Nova Nano scanning electron microscope) were used to conduct a comparative analysis of the content of macronutrients in the tissue of myocardial autopsy of the patients of senile age with chronic heart failure depending on the degree of myocardial contractility - the ejection fraction of the left ventricle. Results: According to the created profiles of maps of macronutrient tissue composition and calculations of heterogeneity, it was found that changes in myocardial tissue of senile patients with systolic dysfunction were represented by significant differences in the heterogeneity of macronutrient distribution (Ca2+, K+, Mg2+, and Na+), while statistically significant differences in the absolute values of macronutrient content in cardiomyocytes were absent. Conclusion: Thus, areas of increased Ca2+ content of Group U1 indicate a local calcium overload of CMC, which results in local contractile dysfunction of myocardial tissue. This statement is reasoned by the presence of dyssynchrony confirmed by the EchocG method in patients of this group.

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    Author(s) Name:

    Olga A. Osipova1 , Alexander A. Komisov1 , Nina I. Zhernakova1 , Andrey I. Golovin1 , Olga M. Godlevskaya2

    Affiliation(s) Name:

    1 Belgorod State University, Belgorod, Russia,

    2 Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine

    *Corresponding author: Olga A. Osipova, Belgorod State University, Belgorod, Russia.

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    Author:

    Olga A. Osipova1 , Alexander A. Komisov1 , Nina I. Zhernakova1 , Andrey I. Golovin1 , Olga M. Godlevskaya2

    Title:Analysis of the influence of chronic heart failure type on changes in the microelement composition of myocardial tissue in patients of senile age
    Journal:Drug Invention Today
    Vol(issue):10 (December)
    Year:2018
    Page No: (3461-3465)
  • Experimental Methods Keywords

    Methodology: Optical plasma emission spectrometry ,scanning electron microscopy (FEI Nova Nano scanning electron microscope)
    Research Materials:Chronic heart failure

Keywords

Chronic heart failure Heart the content of macroelements Mapping of the trace element composition of heart tissue Scanning electron microscopy

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