Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002927
Title: Pharmacological approaches to the correction of radiation- induced endothelial dysfunction
Category: Pharmacology
Section: Research Article
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    At the end of the past century, a broad relationship between the effects of ionizing radiation and cardiovascular pathology was found. At present, discovery of molecular pathways of the radiation-induced vascular lesion can open up wide opportunities for pharmacological correction. Ionizing radiation damages deoxyribonucleic acid, leading to genotoxic stress and secretory phenotype associated with aging (senescence-associated secretory phenotype). It means that the cell is prone to hyperproduction of a wide range of pro-inflammatory cytokines and chemokines, matrix proteases, and growth factors, and is also in a state of oxidative stress. Ionizing radiation activates inducible nitric oxide (NO) synthase transcription and increases nitrite content. Since the inducible form of NO synthase has a very high activity, there is the resulting NO interacts with reactive oxygen species, increasing nitrosative stress nitrosative stress leads to the destruction of arginine and aggravates endothelial dysfunction. In accordance with the described pathogenesis, several groups of pharmacological preparations including statins, antioxidants, angiotensin-converting enzyme inhibitors, erythropoietin, sulfur-containing compounds, and melatonin can be proposed for the radiation-induced endothelial dysfunction. Therefore, remote complications of radiotherapy, among which the cardiovascular occupy a leading position, are becoming increasingly important.

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    Author(s) Name:

    Karen V. Saroyan, Mikhail V. Sytnik, Olesya A. Puchenkova, Eduard S. Miller, Vladislav O. Soldatov*, Vladimir Y. Provotorov, Pavel A. Galenko-Yaroshevsky

    Affiliation(s) Name:

    Department of Pharmacology and Clinical Pharmacology Institute of Medicine, Belgorod State University, Belgorod, Russian

    *Corresponding author: Vladislav O. Soldatov, Department of Pharmacology and Clinical Pharmacology, Belgorod National Research University, Belgorod - 308 015, Russia.

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    Author:

    Karen V. Saroyan, Mikhail V. Sytnik, Olesya A. Puchenkova, Eduard S. Miller, Vladislav O. Soldatov*, Vladimir Y. Provotorov, Pavel A. Galenko-Yaroshevsky

    Title:Pharmacological approaches to the correction of radiation- induced endothelial dysfunction
    Journal:Drug Invention Today
    Vol(issue):10 (December [ Special Issue 4 ])
    Year:2018
    Page No: (3586-3590)
  • Experimental Methods Keywords

    Methodology:Pharmacological approaches
    Research Materials:Radiation

Keywords

Endothelial dysfunction Endothelioprotectors Radiation Radioprotectors

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