Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002930
Title: Risk factors for the preservation of morphological changes in the gastric mucosa after eradication therapy for Helicobacter pylori infection in children with chronic gastritis
Category: Pharmacology
Section: Research Article
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    We conducted a clinical, morphofunctional examination and standard treatment of 155 children with chronic gastroduodenitis associated with Helicobacter pylori (HP) infection. Subsequently, 100 children were examined after 3 and 6 months of proven HP eradication. It was revealed that after 6 months lymphoplasmacytic infiltration of the gastric mucosa (GM) preserved in 37% of cases, and unspecified atrophy - in 9%, increased C3 and C4 components of the compliment - in 19% of children, antroduodenal discoordination on the background of postprandial secretin and cholecystokinin level - in 25%, as well as disorders of the intestinal microbiota. Factors that have a prognostic effect on the preservation of inflammatory changes in the GM according to discriminant analysis include the presence of the pathogenicity factor HP (CagA+), changes in the intestinal microbiota, impaired motor function of the stomach, changes in the immune system (increased C3 and C4 components of the compliment), a vegetative dysregulation, and the presence of comorbid pathology (more than three associated diseases).

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    Author(s) Name:

    Margarita M. Gurova1,2 *, Tatyana А. Romanova1 , Valeria P. Novikova2 , Valentina S. Popova1

    Affiliation(s) Name:

    1 Department of Pediatrics With a Course of Children’s Surgical Diseases, Belgorod State University, 308015, Belgorod, Russia,

    2 St. Petersburg State Pediatric Medical University, 194100, St. Petersburg, Russia

    *Corresponding author: Margarita M. Gurova, Department of Pediatrics with a Course of Children’s Surgical Diseases, Belgorod State University, 308015, Belgorod, Pobeda Street, 85, Russia.

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    Author:

    Margarita M. Gurova1,2 *, Tatyana А. Romanova1 , Valeria P. Novikova2 , Valentina S. Popova1

    Title:Risk factors for the preservation of morphological changes in the gastric mucosa after eradication therapy for Helicobacter pylori infection in children with chronic gastritis
    Journal:Drug Invention Today
    Vol(issue):10 (December [ Special Issue 4 ])
    Year:2018
    Page No: (3601-3605)
  • Experimental Methods Keywords

    Methodology:Chronic gastroduodenitis, Helicobacter pylori infection, Morphological changes, Gastric motility, Microbiot
    Research Materials:Children

Keywords

Children Chronic gastroduodenitis Helicobacter pylori infection Morphological changes Gastric motility Microbiot

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