Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002932
Title: Ethoxidol influence on the morphofunctional state of the cardiovascular system in conditions of endogenous nitric oxide deficiency
Category: Pharmacology
Section: Research Article
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    Introduction: The search and study of compounds with the ability to improve endothelial function are one of the main tasks of modern pharmacology. One of the promising drugs with endothelial protective activity is the 3-hydroxypyridine derivative ethoxidol. Materials and Methods: The study included 40 Wistar rats, divided into four equal groups: (1) Intact, (2) nitro- L-arginine methyl ester (L-NAME) 25 mg/kg for 7 days, (3) L-NAME (25 mg/kg) + Ethoxidol (50 mg/kg) for 7 days, and (4) L-NAME (25 mg/kg) + ethoxidol (90 mg/kg) for 7 days. To assess the effect of ethoxidol on endothelial function in animals, the coefficient of endothelial dysfunction (CED) was determined. In parallel with this, the morphological picture of the myocardium was studied (the diameter of myocardiocytes was determined), the carotid arteries (the intima-media ratio was determined), and the mass of adrenal glands. Results: The 7-day administration of L-NAME led to the development of severe endothelial dysfunction. The use of ethoxidol on the background of relatively high blood pressure values reduced CED by 30% with a low dose and by 49% with a large dose. With a relatively high diameter of cardiomyocytes in all studied groups that received L-NAME, a significant (P ≤ 0.05) difference with control was obtained in all the regimens of therapy. When studying the intima-media ratio in the carotid artery, a significant decrease in the ratio to the control in the group treated with ethoxidol at a dose of 90 mg/kg was also obtained. Significant differences in the mass of the adrenal glands when comparing the studied groups were not obtained. Conclusions: The study of endothelial protective activity in modeling the deficiency of endogenous nitric oxide demonstrated that ethoxidol has pronounced endothelio-, vaso-, and cardio-protective activity.

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    Author(s) Name:

    Olesya A. Puchenkova, Oksana V. Dudchenko, Vladislava S. Veselova, Eduard S. Miller, Pavel D. Kolesnichenko, Vladislav O. Soldatov*, Tatiana G. Pokrovskaya, Sergey V. Povetkin

    Affiliation(s) Name:

    Department of Pharmacology and Clinical Pharmacology, Belgorod State University, 85, Pobedy Street, Belgorod, 308015, Russia

    *Corresponding author: Vladislav O. Soldatov, Department of Pharmacology and Clinical Pharmacology, Belgorod State University, 85, Pobedy Street, Belgorod, 308015, Russia.

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    Author:

    Olesya A. Puchenkova, Oksana V. Dudchenko, Vladislava S. Veselova, Eduard S. Miller, Pavel D. Kolesnichenko, Vladislav O. Soldatov*, Tatiana G. Pokrovskaya, Sergey V. Povetkin

    Title:Ethoxidol influence on the morphofunctional state of the cardiovascular system in conditions of endogenous nitric oxide deficiency
    Journal:Drug Invention Today
    Vol(issue):10 (December [ Special Issue 4 ])
    Year:2018
    Page No: (3609-3613)
  • Experimental Methods Keywords

    Methodology:Antioxidants,cardiovascular system
    Research Materials:Ethoxidol, Nitro-L-arginine methyl ester

Keywords

Antioxidants Endothelial dysfunction Ethoxidol Nitro-L-arginine methyl ester Rats

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