Journal: Drug Invention Today

Article Id: JPRS-D(DD)-00002987
Title: Improvement of solubility and bioavailability of aceclofenac using cocrystallization
Category: Drug (Discovery/Development)
Section: Research Article
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    Aim: The aim of the present investigation was to carry out the in vitro and in vivo studies of the cocrystals of a poorly soluble BCS Class II drug aceclofenac with two selected cocrystal formers, i.e., gallic acid and nicotinamide and hence to improve its solubility and bioavailability. Materials and Methods: The in vitro dissolution studies of the cocrystals which were formed by solvent evaporation method in the stoichiometric ratio of 1:1 after screening were carried out in pH 1.2 buffer solution using Shimadzu 1201 UV-Visible spectrophotometer. The in vivo bioavailability studies were carried out on adult male New Zealand albino rabbits following a parallel design. The blood samples were analyzed using high-performance liquid chromatography. The various pharmacokinetic parameters such as Cmax, Tmax, and area under the curve for the two cocrystals were calculated. Conclusion: Both the cocrystals showed a better dissolution profile than the pure drug and the physical mixture of the pure drug and the cocrystals former in the in vitro dissolution studies. The oral bioavailability also showed a significant increase of 1.77 and 1.37 times when compared to that of pure aceclofenac (P < 0.05).

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    Author(s) Name:

    Sushma Verma1,2,3 *, Arun Nanda3 , S.P. Basu1,2

    Affiliation(s) Name:

    1 Pharmacy Institute, NIET, Plot 19, KP-II Greater Noida, Uttar Pradesh, India,

    2 Faculty of Pharmacy, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India,

    3 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India

    *Corresponding author: Sushma Verma, Pharmacy Institute, NIET, Greater Noida, Uttar Pradesh, India - 201 306.

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    Author:

    Sushma Verma1,2,3 *, Arun Nanda3 , S.P. Basu1,2

    Title:Improvement of solubility and bioavailability of aceclofenac using cocrystallization
    Journal:Drug Invention Today
    Vol(issue):11 (January)
    Year:2019
    Page No: (59-63)
  • Experimental Methods Keywords

    Methodology:Bioavailability studies, Cocrystals, Dissolution studies
    Research Materials:Aceclofenac

Keywords

Aceclofenac Bioavailability studies Cocrystals Dissolution studies

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