Journal: Drug Invention Today

Article Id: JPRS-D(DD)-00002992
Title: Screening, preparation, and characterization of aceclofenac cocrystals
Category: Drug (Discovery/Development)
Section: Research Article
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    Aim: The aim of the present investigation was to prepare cocrystals of a poorly soluble biopharmaceutical classification system Class - II drug, aceclofenac after screening to enhance its solubility and in turn the bioavailability. Materials and Methods: The screening of the cocrystal formers was done by calculating the solubility parameters using Hoftyzer and Van Krevelen solubility parameters and slurry crystallization technique using seven cocrystal formers. Cocrystals of the drug were prepared using solvent evaporation technique using the selected cocrystal formers, that is, Gallic acid and nicotinamide in the stoichiometric ratio of 1:1. Characterization of the prepared cocrystals was done using differential scanning calorimetry, Fourier-transform infrared studies, X-ray diffraction, and scanning electron microscopic techniques. Conclusion: All the four characterization techniques confirmed the formation of cocrystals of the drug thereby establishing cocrystallization as the method for improving the physiochemical properties of an active pharmaceutical ingredient.

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    Author(s) Name:

    Sushma Verma1,2 *, Arun Nanda3 , S.P. Basu1

    Affiliation(s) Name:

    1 Pharmacy Institute, NIET, Plot 19, KP-II Greater Noida, Uttar Pradesh, India,

    2 Faculty of Pharmacy, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India,

    3 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India

    *Corresponding author: Sushma Verma, Pharmacy Institute, NIET, Greater Noida, Uttar Pradesh – 201306, India.

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    Sushma Verma1,2 *, Arun Nanda3 , S.P. Basu1

    Title:Screening, preparation, and characterization of aceclofenac cocrystals
    Journal:Drug Invention Today
    Vol(issue):11 (January)
    Page No: (81-87)
  • Experimental Methods Keywords

    Methodology:Cocrystals, Hoftyzer, Slurry crystallization technique, Van Krevelen solubility parameters
    Research Materials:Aceclofenac


Aceclofenac Cocrystals Hoftyzer Slurry crystallization technique Van Krevelen solubility parameters

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