Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-000030
Title: Formulation and in vitro evaluation of niosome encapsulated acyclovir
Category: Pharmaceutics
Section: Research Article
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  • Abstract

    Acyclovir entrapped niosomes were prepared by hand shaking and ether injection process with different ratios of (1:1, 1;2 and 1:3) cholesterol (CHOL) and Span-80 (Non-ionic surfactant).The niosomes prepared were in the size range of 0.5- 5 microns in the case of hand shaking process and 0.5-2.5 microns in the case of Ether injection process. The order of encapsulation efficiency increases when span-80 concentration was increased. In-vitro release study on acyclovir niosomes indicates 76.64% release for formulation prepared with CHOL: Span-80 (1:1) and it takes an extended period of 1 day and 16 h for release.

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  • About the authors and Affiliations

    Author(s) Name:

    Manivannan Rangasamy*, Balasubramaniam Ayyasamy,

    Senthilkumar Raju1,Sandeep Gummadevelly2 and Sanaullah Shaik2

    Affiliation(s) Name:

    1Department of Pharm.Chemistry, Swamy Vivekanandha College of pharmacy, Elayampalayam, Namakkal, Tamilnadu, India. 

    2Department of Pharmaceutics, J.K.K.M.M.R.F, College of Pharmacy, B.Komarapalayam, Pin Code: 638 183, Namakkal, Tamilnadu, India.

    For correspondence:

    Manivannan Rangasamy, Dept.of Pharmaceutics, JKKMMRF’s college of Pharmacy, B.
    Komarapalayam, Namakkal, Tamilnadu, India.


    E-mail: manivannan_biotech@yahoo.co.in

     


    Received on: 10-07-2008; Accepted on :02-10-2008

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    Author:

    Manivannan Rangasamy*, Balasubramaniam Ayyasamy,

    Senthilkumar Raju1,Sandeep Gummadevelly2 and Sanaullah Shaik2
    Title:Formulation and in vitro evaluation of niosome encapsulated acyclovir
    Journal:Journal of Pharmacy Research
    Vol(issue):1 (Oct-December 2008)
    Year:2008
    Page No: (163-166)

  • Experimental Methods Keywords

    Methodology:Niosomes, Hand-Shaking process, Ether Injection process,VESICLE SIZE DETERMINATION
    Research Materials:Acyclovir

Keywords

Acyclovir Niosomes Cholesterol Span-80 Encapsulation.

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