Journal: Drug Invention Today

Article Id: JPRS-DFP-00003023
Title: Preliminary test of utilization of Aspergillus niger in the biotransformation of geraniol and its identification
Category: Drugs from Plants
Section: Research Article
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    Background: Essential oils (EOs) have gained new interest in several aspects. As a natural product, EOs have attractive physicochemical characteristics with high added values that are environmentally friendly. EO also has diverse and relevant biological activities. A number of studies have highlighted the antimicrobial effects of EO even on multiresistant bacteria. Due to the complex chemical composition of EO, EO has a broad spectrum of biological and antimicrobial activity (antibacterial, antifungal, antiviral, pest control, and insect repellent). Cymbopogon nardus (L.) Rendle is one of the plants that contain EOs, usually known as citronella. citronella or C. nardus (L.) Rendle is one of the Cymbopogon species with quintessence oil which is widely used in the production of citronella, geraniol, citronellol, food, beverages, fragrances, soaps, body care products, and pharmaceutical products. The biotransformation study of geraniol, nerol, and citral by Aspergillus niger have been reported that the main bioconversion products obtained from geraniol and nerol by liquid culture of A. niger are linalool and α-terpineol. Aim: This study aims to utilize A. niger UICC 1012 for the biotransformation process of geraniol to obtain other compounds. Result: The results of identification with gas chromatography-mass spectroscopy showed that the biotransformation product of geraniol was linalool and alpha-terpineol. The value of RT and peak areas respectively; 12.657 and 145.009.110; 16.340 and 4.567.385 (day-1); 12.820 and 409.287.950; 16.422 and 35.681.840 (day-7). Conclusion: A. niger UICC 1012 can be used for biotransformation of geraniol to obtain linalool and alpha-terpineol.

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    Author(s) Name:

    Yelfi Anwar1,2 *, Elvina Dhiaul Iftitah3 , Partomuan Simanjuntak4 , Shirly Kumala5

    Affiliation(s) Name:

    1 Doctoral Program, Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia,

    2 Faculty of Pharmacy, University of 17 August 1945, Jakarta, Indonesia,

    3 Department of Chemistry, Faculty of Math and Science, University of Brawijaya, Malang, Indonesia,

    4 Research Center for Biotechnology, Indonesian Institute of Science, Cibinong, Bogor, Indonesia,

    5 Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia

    *Corresponding author: Yelfi Anwar, Doctoral Program, Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia.

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    Author:

    Yelfi Anwar1,2 *, Elvina Dhiaul Iftitah3 , Partomuan Simanjuntak4 , Shirly Kumala5

    Title:Preliminary test of utilization of Aspergillus niger in the biotransformation of geraniol and its identification
    Journal:Drug Invention Today
    Vol(issue):10 (December [ Special Issue 5 ])
    Year:2018
    Page No: (3794-3797)
  • Experimental Methods Keywords

    Methodology:Biotransformation, Gas chromatography-Mass spectroscopy,
    Research Materials: Aspergillus niger, Geraniol

Keywords

Aspergillus niger Biotransformation Gas chromatography-Mass spectroscopy Geraniol

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