Journal: Drug Invention Today

Article Id: JPRS-P col-00003027
Title: Influence of mulberry leaf extract (Morus alba L.) on diuretic activity of male white Wistar strain rat
Category: Pharmacology
Section: Research Article
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    Background: The mulberry leaf (Morus alba L.) is a traditional medicinal plant that can be used as a diuretic. Aim: This research aimed to know the diuretic effect of mulberry leaf ethanol extract in male white Wistar strain rats using Lipschitz method and ethanol extract optimum dose of mulberry leaf as diuretic. Methods: The rats were devided into five groups; each group is consisted of 5 rats and then given treatment. The categorization of groups is as follows: Normal PGA group 2%, furosemide compound group 3.6 mg/kg body weight (BW), dose 1 group extract 140 mg/kg BW, dose 2 group extract 240 mg/kg BW, and dose 3 group extract 420 mg/kg BW. Each group is put in a metabolism cage, and its urine was collected for testing; diuretic effect was done by measuring urine volume for 6 h. Results: The data were analyzed by one-way analysis of variance. The results showed that giving mulberry leaf can produce the biggest urine volume with dose 420 m/kg BB and approach urine volume of the comparison group (furosemide). Statistically, it was different if it was compared to normal control group volume with level α = 0.01. Conclusion: Mulberry leaf extract had diuretic effect with mechanism increase extractions Na and Cl (Saluretic) effective dose this extract was 420 mg/Kg Bb.

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    Author(s) Name:

    Dytha Andri Deswati*, Sri Maryam

    Affiliation(s) Name:

    Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Al-Ghifari, Bandung, West Java, Indonesia

    *Corresponding author: Dytha Andri Deswati, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Al-Ghifari, Bandung, West Java, Indonesia

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    Author:

    Dytha Andri Deswati*, Sri Maryam

    Title:Influence of mulberry leaf extract (Morus alba L.) on diuretic activity of male white Wistar strain rat
    Journal:Drug Invention Today
    Vol(issue):10 (December [ Special Issue 5 ])
    Year:2018
    Page No: (3811-3813)
  • Experimental Methods Keywords

    Methodology:Diuretic
    Research Materials:Morus alba L

Keywords

Diuretic Extract Morus alba L. Mulberry leaf

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