Journal: Drug Invention Today

Article Id: JPRS-P col-00003031
Title: Antifungal activity of ginger oil against clinical isolates of Candida species
Category: Pharmacology
Section: Research Article
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    Introduction: The use of essential oils from herbs and spices is a novel antimicrobial treatment to reduce the initial microorganism loads. In herbs and spices, there are many antimicrobial compounds exhibiting a wide range of activities against bacteria, yeasts, and fungi. Essential oils from plants have been suggested as natural preservatives. Thus, the aim of the present study is to assess the antifungal activity of ginger oil against clinical isolates of Candida species. Materials and Methods: A total of 20 non-repetitive clinical isolates of Candida species were collected from different samples of immunocompromised individuals attending a medical hospital, in Chennai. They were characterized by carbohydrate fermentation and assimilation tests and confirmed. Isolates were preserved in semisolid Sabouraud chloramphenicol semisolid stock and stored at 4°C until further use. Candida species were further characterized using HiCrome candida differential agar (HiMedia, Mumbai). Results: Clinical isolates of Candida sp. were inhibited from 0.125% to 1% of ginger oil. The minimal inhibitory concentration of ginger oil was appeared to be 0.25% for Candida spp. Conclusion: The ginger oil is found to have antifungal activity against Candida spp. Since any toxic or irritant property of ginger oil has to be under consideration, ginger oil can be used as alternative and complementary agent for controlling fungal infections.

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    Author(s) Name:

    Prasanna Guru1 , Gopinath2 , Meenakshi Krishnan3*

    Affiliation(s) Name:

    1 Department of General Dentistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Microbiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    3 Department of Oral Medicine and Radiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding Author: Meenakshi Krishnan, Department of Oral Medicine and Radiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 162, Poonamallee High Road, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    Prasanna Guru1 , Gopinath2 , Meenakshi Krishnan3*

    Title:Antifungal activity of ginger oil against clinical isolates of Candida species
    Journal:Drug Invention Today
    Vol(issue):10 (December [ Special Issue 5 ])
    Year:2018
    Page No: (3832-3836)
  • Experimental Methods Keywords

    Methodology:Antifungal activity
    Research Materials:Ginger oil

Keywords

Antifungal Candida species Chloramphenicol Cytoprotective Ginger oil Medicinal plants Sabouraud agar

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