Journal: Drug Invention Today

Article Id: JPRS-P col-00003035
Title: Role of interleukin 10 as an anti-inflammatory cytokine in periodontal infection
Category: Pharmacology
Section: Review Article
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  • Abstract

    Periodontal diseases comprise a wide range of inflammatory conditions that affect the supporting structures of the teeth (the gingiva, bone, and periodontal ligament), which could lead to tooth loss and contribute to systemic inflammation. A complex network of pro- and anti-inflammatory cytokines acts in inflamed periodontal tissues. Among other cytokines, interleukin-10 (IL-10) is an important multifunctional cytokine. Periodontal inflammation may involve both an increase in inflammatory stimulators such as IL-1 and a decrease in inflammatory inhibitors like IL-10. IL-10 has been also regarded as an important regulator of bone homeostasis, in homeostatic, and inflammatory conditions. Hence, IL-10 given the role of IL-10 in bone remodeling, the use of IL-10 for inhibiting bone resorption and reducing inflammation may be beneficial for the treatments of periodontitis.

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    Author(s) Name:

    Godlin Jeneta1 , Caroline Jacob2 , Sree Devi 3*

    Affiliation(s) Name:

    1 Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Periodontitis, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    3 Department of Oral Medicine and Radiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Sree Devi, Department of Oral Medicine and Radiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, 162, Poonamallee High Road, Chennai – 600 077, Tamil Nadu, India.

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    Author:

    Godlin Jeneta1 , Caroline Jacob2 , Sree Devi 3*

    Title:Role of interleukin 10 as an anti-inflammatory cytokine in periodontal infection
    Journal:Drug Invention Today
    Vol(issue):10 (December [ Special Issue 5 ])
    Year:2018
    Page No: (3851-3855)
  • Experimental Methods Keywords

    Methodology:anti-inflammatory , periodontal infection
    Research Materials:interleukin 10

Keywords

Cytokines Inflammation Interleukin Periodontitis

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