Journal: Drug Invention Today

Article Id: JPRS-P col-00003040
Title: The epidermal growth factor receptor as target for cancer therapy
Category: Pharmacology
Section: Review Article
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    Human carcinomas express high levels of receptors in the epidermal growth factor (EGF) receptor family, it includes two important EGF receptors; they are EGF receptor (EGFR) and ErbB2. Function of these receptors is more useful for anticancer treatments. The monoclonal antibodies (MAbs) block the activation of EGFR and ErbB2. A humanized anti-ErbB2 is active and recently approved in combination with paclitaxel for the therapy of patients with metastatic ErbB2 over aggressive breast cancer, a chimeric anti-EGFR MAb is active in combination with radiation therapy and reverses resistance to chemotherapy.

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    Author(s) Name:

    M. Indhumathi 1 , M. P. Brundha1 , Hemavathy O. R2*

    Affiliation(s) Name:

    1 Department of General Pathology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: O.R. Hemavathy, Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 162, Poonamallee High Road, Chennai - 600077, Tamil Nadu, India

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    Author:

    M. Indhumathi 1 , M. P. Brundha1 , Hemavathy O. R2*

    Title:The epidermal growth factor receptor as target for cancer therapy
    Journal:Drug Invention Today
    Vol(issue):10 (December [ Special Issue 5 ])
    Year:2018
    Page No: (3871-3874)
  • Experimental Methods Keywords

    Methodology:Cancer therapy
    Research Materials:Epidermal growth factor receptor, Monoclonal antibodies

Keywords

Anticancer treatment Carcinoma Chemotherapy Epidermal growth factor receptor Monoclonal antibodies

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