Journal: Drug Invention Today
Title: The epidermal growth factor receptor as target for cancer therapy
Category: Pharmaceutics
Section: Review Article
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Abstract
Human carcinomas express high levels of receptors in the epidermal growth factor (EGF) receptor family, it includes two important EGF receptors; they are EGF receptor (EGFR) and ErbB2. Function of these receptors is more useful for anticancer treatments. The monoclonal antibodies (MAbs) block the activation of EGFR and ErbB2. A humanized anti-ErbB2 is active and recently approved in combination with paclitaxel for the therapy of patients with metastatic ErbB2 over aggressive breast cancer, a chimeric anti-EGFR MAb is active in combination with radiation therapy and reverses resistance to chemotherapy.
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About the authors and Affiliations
Author(s) Name: M. Indhumathi 1 , M. P. Brundha1 , Hemavathy O. R2*
Affiliation(s) Name: 1 Department of General Pathology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,
2 Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India
*Corresponding author: O.R. Hemavathy, Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 162, Poonamallee High Road, Chennai - 600077, Tamil Nadu, India
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Author: M. Indhumathi 1 , M. P. Brundha1 , Hemavathy O. R2*
Title: The epidermal growth factor receptor as target for cancer therapy Journal: Drug Invention Today Vol(issue): 10 (December [ Special Issue 5 ]) Year: 2018 Page No: (3871-3874) -
Experimental Methods Keywords
Methodology: Cancer therapy Research Materials: Epidermal growth factor receptor, Monoclonal antibodies
Keywords
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