Journal: Drug Invention Today

Article Id: JPRS-P col-00003058
Title: Management of osteoradionecrosis of oral cavity
Category: Pharmaceutics
Section: Review Article
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  • Abstract

    The treatment of head and neck cancer remains a challenge. Despite advances in surgical reconstructive techniques, most patients will require adjuvant therapy in the form of radiotherapy or chemoradiotherapy to improve locoregional control. The short- and long-term side effects of radiotherapy can be difficult to treat. The initial effects of radiotherapy to the oral tissues such as mucositis and loss of taste are troublesome but short-lived resolving within a few weeks. Xerostomia may be more persistent but can be managed with supportive therapy such as sialogogues and artificial saliva. Osteoradionecrosis (ORN) is the long-term and most serious side effect of radiotherapy. ORN develops as irradiation diminishes the bone’s ability to withstand trauma and avoid infection, and it can be facilitated by poor nutrition and hygiene. ORN usually occurs in the mandible and causes chronic pain and surface ulcerations. All patients who require extraction of teeth in a previously irradiated field should be considered at risk of developing ORN.

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    Author(s) Name:

    Nivedhaa Chezhian1, Dhanraj Ganapathy1, Ashish R. Jain1*

    Affiliation(s) Name:

    Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. Ashish R. Jain, Department of Prosthodontics, Saveetha Dental College and Hospital, Saveetha University, Poonamalle High Road, Chennai – 600127, Tamil Nadu, India.

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    Nivedhaa Chezhian1, Dhanraj Ganapathy1, Ashish R. Jain1*

    Title:Management of osteoradionecrosis of oral cavity
    Journal:Drug Invention Today
    Vol(issue):12 (January)
    Page No: (48-52)
  • Experimental Methods Keywords

    Methodology:Radiotherapy, Xerostomia
    Research Materials:osteoradionecrosis


Osteoradionecrosis Radiotherapy Xerostomia

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