Journal: Drug Invention Today

Article Id: JPRS-D(DD)-00003068
Title: Design, characterization, and in vitro evaluation of zaltoprofen solid dispersion as a hollow-type rectal suppository
Category: Drug (Discovery/Development)
Section: Research Article
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    Aim: The present study aims to improve the poor water solubility of zaltoprofen which is a non-steroidal anti-inflammatory drug (NSAIDs) with a potent analgesic effect using solid dispersion then formulate it as a hollow type suppository to be more convenient for geriatric patients. Materials and Method: Zaltoprofen solid dispersions were prepared by solvent evaporation technique in different zaltoprofen: Soluplus® ratios. Results: Among the formulations tested, zaltoprofen solid dispersion preparation using 1:5 (zaltoprofen: Soluplus®) ratio showed the highest solubility and selected for further investigation. Solid dispersion characterization was evaluated by differential scanning calorimetry (DSC), X-ray diffraction study (XRD) and Fourier transformation infrared spectroscopy (FTIR). DSC and XRD analysis showed a complete transformation of zaltoprofen in the solid dispersion from a crystalline state to amorphous state. The selected zaltoprofen solid dispersion was further incorporated into hollow type suppositories using witepsol H 35 as a suppositories base. The hollow type suppositories were evaluated for hardness test (breaking strength), melting time, softening time and in vitro drug dissolution rate. Formula F8 containing zaltoprofen solid dispersion in the whole of hollow type suppository showed the shortest and significantly the highest dissolution rate profile (100% within 15 min) compared to other hollow type suppository formulas prepared that contain zaltoprofen powder in its whole. Conclusion: It is concluded that the development of zaltoprofen solid dispersions using Soluplus® as hollow-type suppositories could be used as a promising approach for improving the solubility of poorly water-soluble drugs.

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    Author(s) Name:

    Shaimaa Nazar Abd Alhammid*, Manar Adnan Tamer, Mais Abd-Alridha Abbod

    Affiliation(s) Name:

    Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq

    *Corresponding author: Shaimaa Nazar Abd Alhammid, Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq

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    Author:

    Shaimaa Nazar Abd Alhammid*, Manar Adnan Tamer, Mais Abd-Alridha Abbod

    Title:Design, characterization, and in vitro evaluation of zaltoprofen solid dispersion as a hollow-type rectal suppository
    Journal:Drug Invention Today
    Vol(issue):12 (January)
    Year:2019
    Page No: (83-90)
  • Experimental Methods Keywords

    Methodology:Design, characterization, in vitro evaluation
    Research Materials: Zaltoprofen

Keywords

Hollow-type suppositories Solid dispersions Soluplus Witepsol H 35 Zaltoprofen

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