Journal: Drug Invention Today

Article Id: JPRS-P col-00003079
Title: Correlation of salivary nitric oxide and stress levels in patients with chronic periodontitis - A biochemical study
Category: Pharmaceutics
Section: Research Article
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    Background: The past millennium has witnessed tremendous research regarding attempts to enhance our understanding of the etiopathogenesis of periodontal disease. Nitric oxide (NO), a free radical gas, is a noxious chemical in the atmosphere but in small controlled concentrations in the body, acts as a physiological and pathophysiological mediator and plays an important role in biological systems. It is known that stress mechanisms contribute to onset, exacerbation, and maintenance of oral inflammatory diseases and it is also known to generate a plethora of free radicals including NO. Hence, this study performed to explore the salivary NO levels and correlate it with chronic periodontitis and the patients stress level. Materials and Methods: A total of 60 subjects who were in the age group of 30–55 years, who participated in this study participated and were divided into two groups: Group I, which includes 20 healthy nonsmoking subjects and Group II, 20 subjects who are non-smokers with chronic periodontitis. The biochemical estimation of NO in the collected saliva was performed using the Griess colorimetric reaction. The measurement of stress levels for all the patients was requested to fill up a stress audit questionnaire by Miller and Smith to measure their stress levels.Statistical Analysis and Results: The statistical comparisons were done under the Griess Reaction. There were statistically significant salivary levels of NO in the group of periodontitis (group II) as compared to those in the healthy controls (group I). The collected data were subjected to statistical analysis through SPSS for windows (version 16.0). The statistical methods applied were descriptive statistics, one- way analysis of variance, Scheffe’s post hoc test, correlation analysis, independent samples t-test, and regression analysis. Conclusion: NO plays an important complex role in the immunoinflammatory process and the remodeling and maintenance of osseous structures. The salivary NO levels which are increased in patients with periodontitis and the positive correlation of salivary NO levels with the patients stress levels in this present study indicated NO being a potent modulator of inflammatory disease processes.

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    Author(s) Name:

    N. Mani Sundar1 *, A. Julius2 , Mohan Valiathan3 , Krishna Raj 4 , Preethe Paddmanabhan5

    Affiliation(s) Name:

    1 Department of Periodontist and Oral Implantologist, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India,

    2 Department of Biochemistry, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India,

    3 Department of Periodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India,

    4 Division of Periodontics, Rajah Muthiah Dental College and Hospital, Annamalai University, Chidambaram, Tamil Nadu, India,

    5 Department of Periodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. N. Mani Sundar,PhD Research Scholar, Department of Periodontist and Oral Implantologist, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

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    Author:

    N. Mani Sundar1 *, A. Julius2 , Mohan Valiathan3 , Krishna Raj 4 , Preethe Paddmanabhan5

    Title:Correlation of salivary nitric oxide and stress levels in patients with chronic periodontitis - A biochemical study
    Journal:Drug Invention Today
    Vol(issue):12 (January)
    Year:2019
    Page No: (141-147)
  • Experimental Methods Keywords

    Methodology: A biochemical study, Griess colorimetric reaction, Miller and Smith to measure their stress
    Research Materials:60 patients

Keywords

Nitric oxide Periodontitis Stress levels

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