Journal: Drug Invention Today

Article Id: JPRS-P col-00003080
Title: The potential antidiabetic and anti-inflammatory activity of Zingiber zerumbet ethanolic extracts and Channa striata powder on albino Wistar mice
Category: Pharmaceutics
Section: Research Article
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    Aim: The aim of this research to evaluate the activities of Zingiber zerumbet ethanolic extract (ZZEE) and Channa striata powder (CSP) used an animal model, albino Wistar mice, induced by alloxan; meanwhile, anti-inflammatory activity was induced using carrageenan to produce paw edema. Materials and Methods: The study used a post-test design with five treatment groups, each of which consisted of five mice. The groups for anti-inflammation study were negative control, positive control, 150 mg/kgBW dose of CSP, 150 mg/kgBW dose of ZZEE, and 150 mg/kgBW dose of the combination of CSP-ZZEE. The treatment groups of antidiabetic study were as negative control, positive control, 300 kg/kgBW dose of ZZEE, 300 mg/kgBW dose of CSP, and 300 mg/kgBW dose of the combination of ZZEE and CSP. Results: The results showed the percentage inhibition of the paw edema of ZZEE, CSP, combination of ZZEE-CSP, and positive control groups at 40.01 ± 7.19, 35.25 ± 8.48, 36.56 ± 7.22, and 36.10 ± 2.89%, respectively, whereas the percentage of decreasing capability of blood sugar level of ZZEE, CSP, combination of ZZE-CSP, and positive control successively was at 61.09 ± 16.20, 33.78 ± 26.67, 69.59 ± 13.53, and 74.72 ± 9.90%. Conclusions: There was a synergistic effect on anti-diabetes activity of ZZEE and CSP. Meanwhile in anti-inflammation study did not perform synergistic effect.

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    Author(s) Name:

    Muhtadi Muhtadi 1 *, Andi Suhendi 1 , E. M. Sutrisna2

    Affiliation(s) Name:

    1Pharmaceutical Chemistry of Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Jl. A. Yani Tromol Pos I, Pabelan, Kartasura, Surakarta 57102, Indonesia,

    2Department of Pharmacology, Faculty of Medicine, Universitas Muhammadiyah Surakarta, Indonesia

    *Corresponding author: Muhtadi, Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Jl. A. Yani Tromol Pos I, Pabelan, Kartasura, Surakarta 57102, Indonesia.

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    Author:

    Muhtadi Muhtadi 1 *, Andi Suhendi 1 , E. M. Sutrisna2

    Title:The potential antidiabetic and anti-inflammatory activity of Zingiber zerumbet ethanolic extracts and Channa striata powder on albino Wistar mice
    Journal:Drug Invention Today
    Vol(issue):12 (January)
    Year:2019
    Page No: (148-153)
  • Experimental Methods Keywords

    Methodology:Antidiabetic activity, Anti-inflammatory
    Research Materials: Channa striata, Zingiber zerumbet

Keywords

Antidiabetic activity Anti-inflammatory Channa striata Zingiber zerumbet

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