Journal: Drug Invention Today

Article Id: JPRS-P col-00003083
Title: Basal cell carcinoma - A review
Category: Pharmaceutics
Section: Review Article
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    Basal cell carcinoma (BCC) is a local and invasive carcinoma of the epidermoid basal cells. These are mostly caused due to ultraviolet radiation, sun exposure, radiotherapy, etc. They should be identified at the earliest to prevent massive invasion of tissues and for effective treatment. BCC constitutes about 80% of all non-melanoma skin cancers and is most commonly found in head and neck region. BCC is the most common malignancy in people with white skin. Although mortality is considerably less and rarely metastasize, it causes morbidity. They are also at great risk of developing into other malignancies. The incidence of BCC is rapidly increasing and a number of treatment modalities are available. While typically a slow-growing tumor for which metastases is rare, BCC can be locally destructive and disfiguring. Given the vast prevalence of this disease, there is a significant overall burden on patient well-being and quality of life. The current mainstay of BCC treatment involves surgical modalities such as electrodesiccation and curettage, excision, cryosurgery, and Mohs micrographic surgery. Such methods are typically reserved for localized BCC and offer high 5-year cure rates but come with the risk of functional impairment, disfigurement, and scarring. Numerous therapeutic methods established for the treatment of BCC, having their advantages or disadvantages, do not absolutely dissolve the risk of relapses. The early diagnostics based on the good knowledge and timely organized and adequate treatment is a precondition for better prognosis. The treatment modality utilized is dependent on both the tumor type and the patient. This article reviews about the etiology, clinical features, and treatment modalities of BCC.

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    Author(s) Name:

    R. Balaji 1 , Revathi Duraisamy1 , M. P. Santhosh Kumar2 *

    Affiliation(s) Name:

    1 Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. M. P. Santhosh Kumar, Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 162, Poonamalle High Road, Velappanchavadi, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    R. Balaji 1 , Revathi Duraisamy1 , M. P. Santhosh Kumar2 *

    Title:Basal cell carcinoma - A review
    Journal:Drug Invention Today
    Vol(issue):12 (January)
    Year:2019
    Page No: (162-166)
  • Experimental Methods Keywords

    Methodology:Basal cell carcinoma, Malignancy, Metastasis
    Research Materials:Skin cancer, Tumor

Keywords

Basal cell carcinoma Malignancy Metastasis Skin cancer Tumor

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