Journal: Drug Invention Today

Article Id: JPRS-P col-00003091
Title: Morphology of the rat’s brain in four vessels model of ischemic stroke after administration of carbamylated darbepoetin
Category: Pharmacology
Section: Research Article
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    Aim: The aim was the study of the cerebroprotective effect of carbamylated darbepoetin in a four-vessel model of rat brain ischemia-reperfusion. Materials and method: Various parts of rat brain were studied in the four-vessel ischemia-reperfusion model in the treatment with carbamylated darbepoetin. The animals were divided into four groups: Intact, pseudo-operated, with a four-vessel model of ischemia without treatment, and a triple preliminary administration of carbamylated darbepoetin. Animals in the third and fourth groups were intraperitoneally injected with carbamylated darbepoetin at a dose of 100 μg/kg at an interval of 3 days. Results: The carotid arteries were isolated, and then the electrocoagulation of the vertebral arteries at the level of the C2-C3 segments of the spinal cord, after which the common carotid arteries were bandaged. The onset of ischemia was controlled with a decrease in the amplitude on the electroencephalogram. Conclusion: The study of the hippocampus and the cerebral cortex after the experiment was performed on days 1 and 3. A massive preconditioning cerebroprotective effect of carbamylated darbepoetin in the fourth group of animals and massive ischemic changes of the hippocampal and cortical neurons in the third group were revealed. These were manifested by karyopyknosis, karyorrhexis, and violation of stratification of CA1-CA3 layers of the hippocampus.

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    Author(s) Name:

    Tverskoy Alexey Vladimirovich*, Pavel D. Kolesnichenko, Olesya V. Shcheblykina, Narine S. Gorbunova, Vitaliy N. Morozov, Tatyana S. Mukhina

    Affiliation(s) Name:

    Department of Human Anatomy, Department of Human Anatomy of the Medical Institute, Federal State Autonomous Educational Institution of Higher Professional Education (Belgorod State National Research University) (NRU BelSU), Pobedy St. 85, Belgorod, 308015, Russia

    *Corresponding author: Tverskoy Alexey Vladimirovich, Department of Human Anatomy of the Medical Institute, Federal State Autonomous Educational Institution of Higher Professional Education (Belgorod State National Research University) (NRU BelSU), Pobedy St. 85, Belgorod, 308015, Russia.

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    Author:

    Tverskoy Alexey Vladimirovich*, Pavel D. Kolesnichenko, Olesya V. Shcheblykina, Narine S. Gorbunova, Vitaliy N. Morozov, Tatyana S. Mukhina

    Title:Morphology of the rat’s brain in four vessels model of ischemic stroke after administration of carbamylated darbepoetin
    Journal:Drug Invention Today
    Vol(issue):10 (December [ Special Issue 5 ])
    Year:2018
    Page No: (3897-3900)
  • Experimental Methods Keywords

    Methodology:cerebroprotective effect ,Cerebral ischemia, Four vessels model, Reperfusion, Hippocampus
    Research Materials: Carbamylated darbepoetin

Keywords

Carbamylated darbepoetin Cerebral ischemia Four vessels model Reperfusion Hippocampus

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