Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-000031
Title: Reparation of solid dispersions of NSAIDS and its mechanism of drug polymers interaction
Category: Pharmaceutics
Section: Research Article
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    This work studied the mechanisms of interaction between Eudragit RSPO and RLPO polymers with 3 Nonsteroidal Anti-inflammatory Drugs: Diflunisal (DIF), Flurbiprofen (FLU) and Piroxicam (PIR). Solid dispersions of Polymers and drugs at different weight ratios were prepared by coevaporation method. The resulting coevaporates were characterized in the solid state (Fourier-transformed infrared spectroscopy (FT-IR) IR, Differential scanning calorimetry, Powder-x-ray diffractometry) as well as by studying the in vitro drug release in a gastroenteric environment. The preparative conditions did not induce changes in the crystalline state of the drugs (Amorphization or polymorphic change). RLPO & RSPO coevaporate usually displayed higher dissolution rates. However, the kinetic evaluation of the dissolution profile suggested that both the drug solubility in the external medium and its diffusion capacity within the polymer network are involved. In the sorption experiments, RLPO showed a greater adsorptive capacity than RSPO, in relation to the greater number of quaternary ammonium functions, which behave as activity sites for the electrostatic interactions. In the presence of Tris-HCl buffer (pH 7.4), drug adsorption was reduced, as a consequence of the competition of the chloride ions with drug anions for the polymer binding sites. DIF and FLU displayed a similar interaction with RSPO and RLPO active sites. PIR’s was different .The different molecular structures of these agents can justify such things. The presence of a carboxyl group (instead of another dissociable acidic moiety, like the hydroxy-enolic one in the PIR molecule) could help explain the strong interaction with RSPO and RLPO polymers’ quaternary ammonium centers. Preliminary studies like ours are important in helping develop better forecasting and increasing the understanding of the incorporation/release behavior of drugs from particulate delivery systems that can be made from these polymers.

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    Author(s) Name:

    Manoranjan Sahu*1, Subhabrato Majumdar1, M.E.Bhanoji Rao1

    Affiliation(s) Name:

    1Roland institute of pharmaceutical sciences, Khodasingi, Berhampur , Orissa-760010,India.

    For correspondence:

    Manoranjan Sahu ,Roland institute of pharmaceutical sciences, Khodasingi, Berhampur, Orissa-760010,India


    E mail: man.enter@rediffmail.com


    Received on: 20.07.2008 Accepted on: 15.09.2008

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    Author:

    Manoranjan Sahu*1, Subhabrato Majumdar1, M.E.Bhanoji Rao1

    Title:Reparation of solid dispersions of NSAIDS and its mechanism of drug polymers interaction
    Journal:Journal of Pharmacy Research
    Vol(issue):1 (Oct-December 2008)
    Year:2008
    Page No: (167-174)
  • Experimental Methods Keywords

    Methodology:mechanisms of interaction
    Research Materials:Eudragit RSPO and RLPO polymers with 3 Nonsteroidal Anti-inflammatory Drugs

Keywords

Eudragit RS100 Eudragit RL100 diflunisal flurbiprofen piroxicam solid dispersions coevaporates

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