Journal: Drug Invention Today

Article Id: JPRS-P col-00003159
Title: Role of growth factors in wound healing
Category: Pharmaceutics
Section: Review Article
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  • Abstract

    The wound healing process involves a series of cellular and biochemical events that ultimately lead to tissue repair and regeneration. These events include hemostasis, inflammation, proliferation, epithelialization, maturation, and remodeling of the scar tissue. Wound healing is an evolutionarily conserved, complex, multicellular process that, in skin, aims at barrier restoration. This process involves the coordinated efforts of several cell types including keratinocytes, fibroblasts, myofibroblasts, smooth muscle cells, endothelial cells, immune cells, macrophages, and platelets. The migration, infiltration, proliferation, and differentiation of these cells will culminate in an inflammatory response, the formation of new tissue and ultimately wound closure. This complex process is executed and regulated by an equally complex signaling network involving numerous growth factors, cytokines, and chemokines. These include epidermal growth factor, fibroblast growth factor (FGF), insulin-like growth factor, keratinocyte growth factor, platelet-derived growth factor, transforming growth factor (TGF), and vascular endothelial growth factor. TGF-β, IL-1, and TGF-α. This review will focus on the specific roles of these growth factors and cytokines during the wound healing process.

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    Author(s) Name:

    N. Ashika Riswana1 , K. R. Don2 *

    Affiliation(s) Name:

    1 Graduate Student, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, India,

    2 Senior Lecturer, Department of Oral and maxillofacial Pathology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: K. R. Don, Department of Oral and Maxillofacial Pathology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 162, Poonamallee High Road, Chennai – 600 077, Tamil Nadu, India

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    Author:

    N. Ashika Riswana1 , K. R. Don2 *

    Title:Role of growth factors in wound healing
    Journal:Drug Invention Today
    Vol(issue):11 (February)
    Year:2019
    Page No: (458-464)
  • Experimental Methods Keywords

    Methodology: Growth factors, Types, Phases, Pharmaceutical consideration,
    Research Materials:Wound healing

Keywords

Growth factors Types Phases Pharmaceutical consideration Wound healing

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