Journal: Drug Invention Today

Article Id: JPRS-P col-00003200
Title: Effect of omega-3 polyunsaturated fatty acids on inflammatory status, lipid levels, and severity of peripheral artery disease measured using ankle-brachial index - A review
Category: Pharmaceutics
Section: Research Article
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    Peripheral artery disease (PAD) is a buildup of plaques causing blockage inside the arteries of the legs which is characterized by either partial or complete obstruction of the arteries of the lower limb, it is one of the common manifestations of atherosclerosis. Various factors such as smoking, diabetes, high blood pressure, and increased cholesterol levels contribute in developing PAD. It has been postulated that PAD is strongly associated with increased serum lipid levels  and inflammatory status , which increases a high risk of cardiovascular disease among these patients. A non-invasive procedure for screening PAD or measuring the disease severity is done using ankle-brachial index (ABI). ABI value <0.9 indicates PAD . An increased omega-3 polyunsaturated fatty acid (n-3 PUFA) intake has been shown to reduce mortality and complications in PAD patients. The cardiac benefits of n-3 PUFAs are attributed to its antiarrhythmic properties; however, it also has some of the additional effect that generally contributes its cardiovascular action . Due to its inflammation resolution phase, it can be used in PAD . Hence, the beneficial effects of n-omega-3 fatty acid for patients with PAD are the focus of this review. If the n-3 PUFA is associated with circulating markers of inflammation, lipid levels, and ABI in patients with PAD, then, a better understanding of this relationship could help guide future treatment of these patients (i.e., nutritional recommendations or supplementation) in an effort to lower disease severity and improve their vascular function.

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    Author(s) Name:

    Neetu Ojha*, P. Shanmugasundaram

    Affiliation(s) Name:

    Department of Pharmacy Practice, School of Pharmaceuticals Sciences, VISTAS, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. P. Shanmugasundaram, Director , School of Pharmaceuticals Sciences, VISTAS, Pallavaram, Chennai – 600 117, Tamil Nadu, India.

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    Author:

    Neetu Ojha*, P. Shanmugasundaram

    Title:Effect of omega-3 polyunsaturated fatty acids on inflammatory status, lipid levels, and severity of peripheral artery disease measured using ankle-brachial index - A review
    Journal:Drug Invention Today
    Vol(issue):11 (March)
    Year:2019
    Page No: (501-504)
  • Experimental Methods Keywords

    Methodology:Ankle-brachial index,, Peripheral artery disease
    Research Materials:Omega-3 polyunsaturated fatty acids

Keywords

Ankle-brachial index Omega-3 polyunsaturated fatty acids Peripheral artery disease

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