Journal: Drug Invention Today

Article Id: JPRS-P col-00003205
Title: Eleutherine americana Merr. extract regulates mitochondrial calcium homeostasis in intra-abdominal adhesion: A computational study
Category: Pharmaceutics
Section: Research Article
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    Aim: Intra-abdominal adhesion (IAA) is the most significant complication after surgery. This study explores the active compound from Eleutherine americana Merr. as a regulator of mitochondrial calcium homeostasis in IAA. This study aimed to evaluate computationally the potential of E. americana Merr. extract as a mitochondrial calcium activator in IAA cases. Materials and Methods: The sample was 14 active compounds from E. americana Merr. extract that was collected from the PubChem database. Prediction as a calcium channel activator was conducted using Prediction of Activity Spectra for Substances SERVER. Human intestinal absorption (HIA) and lethal dose 50 (LD50) were evaluated using SERVER. Protein target and pathway were evaluated using STITCH, and computational analysis was done using Cytoscape. Results: The results showed that 10 bioactives from E. americana Merr. extract have potential as calcium activators (Pa >0.3). The active compound of E. americana Merr. can be easily absorbed in the intestine based on its HIA+ score (HIA >0.9). Conclusion: The application of this extract was possible due to LD50 evaluation that showed that it was less toxic (LD50 <3 mol/kg-BW). E. americana Merr. extract regulates mitochondrial calcium homeostasis, by modulation of two types of the mitochondrial calcium channels, VDAC1 and MARCK (mRyR).

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    Author(s) Name:

    Hery Poerwosusanta1,3 *, Didik Huswo Utomo2 , Zairin Noor3 , Ika Kustiyah Oktaviyanti 4 , Karyono Mintaroem5 , Bambang Pardjianto5 , Moch Aris Widodo5 , Edi Widjajanto5

    Affiliation(s) Name:

    1 Biomedical Science Doctoral Study Program, Faculty of Medicine Brawijaya University, Jalan Veteran Malang - 65145, East Java, Indonesia,

    2 Department of Biology, Faculty of Mathematics and Natural Science, Universitas Brawijaya, Jalan Veteran Malang - 65145, East Java, Indonesia,

    3 Department of Surgery, Universitas Lambung Mangkurat Jalan Brigjen H. Hasan Basri, Kayu Tangi, Banjarmasin, Indonesia,

    4 Department of Pathology Anatomy, Universitas Lambung Mangkurat, Jalan Brigjen H. Hasan Basri, Kayu Tangi, Banjarmasin, Indonesia,

    5 Department of Biomedical Science, Faculty of Medicine, Universitas Brawijaya, Jalan Veteran Malang - 65145, East Java, Indonesia

    *Corresponding author: Hery Poerwosusanta, Biomedical Science Doctoral Study Program, Faculty of Medicine Universitas Brawijaya, Jalan Veteran Malang - 65145, East Java, Indonesia.

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    Author:

    Hery Poerwosusanta1,3 *, Didik Huswo Utomo2 , Zairin Noor3 , Ika Kustiyah Oktaviyanti 4 , Karyono Mintaroem5 , Bambang Pardjianto5 , Moch Aris Widodo5 , Edi Widjajanto5

    Title:Eleutherine americana Merr. extract regulates mitochondrial calcium homeostasis in intra-abdominal adhesion: A computational study
    Journal:Drug Invention Today
    Vol(issue):11 (March)
    Year:2019
    Page No: (526-530)
  • Experimental Methods Keywords

    Methodology:Ligand Preparation, Biological Activity Prediction
    Research Materials:Eleutherine americana Merr. extract

Keywords

Calcium activator Eleutherine americana Merr. MARCK VDAC1

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