Journal: Drug Invention Today

Article Id: JPRS-P col-00003208
Title: Role of toll-like receptor 4 +3725 G/C polymorphism in type 2 diabetes mellitus
Category: Pharmaceutics
Section: Research Article
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    Objective: Activation of intrinsic immune response and consequent chronic low-grade inflammation is believed to be engaged with the pathogenesis of type 2 diabetes. Toll-like receptor 4 (TLR4) assumes a critical part in innate immunity. In this study, we expected to research the potential relationship of +3725 G/C genotypes into toll-like receptor 4 gene and adiponectin with type 2 diabetes mellitus (T2DM). Materials and Methods: A prospective case–controlled study directed on 75 patients with type 2 diabetes likened with 25 control subjects at the medical school of Tanta University, participants were subjected to routine laboratory investigations; fasting plasma glucose, lipid profile. Serum level of adiponectin was done by enzyme-linked immunosorbent assay and genotyping of the TLR4 gene was performed. Results: TLR4 +3725 GC and CC genotypes were significantly decreased in T2DM cases than in controls (P = 0.003 and P = 0.001, respectively), while the GG genotype was significantly higher (80%) in T2DM cases than controls. The frequency of TLR4 +3725 C allele was significantly lower in the T2DM group than controls (P = 0.001). Adiponectin level was significantly higher in CC genotype when compared to GG GC genotype of TLR4 +3725 G/C polymorphism in the patient group (P = 0.001). Biochemical parameters (glucose, cholesterol, triglyceride, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, and serum adiponectin level) established statistically significant correlations between the studied groups (P < 0.05). Body mass index was significantly higher in diabetics Group II. Conclusion: Based on our results, we founded that TLR4 +3725 GC and CC polymorphisms may be a novel protective factor against T2DM. Adiponectin can function as a modulator of multiple obesity-linked diseases by attenuating excessive inflammatory responses in a variety of tissues; it may act as a protective factor against insulin resistance.

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    Author(s) Name:

    Rania Said Anwar Amer1 *, Morad Ahmed Morad1 , Gihan Farouk Attia1 , Nesreen Ahmed Kotb2

    Affiliation(s) Name:

    1Department of Clinical Pathology, Tanta University, Tanta, Gharbia Governorate, Egypt,

    2 Department of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Gharbi Governorate, Egypt

    *Corresponding author: Rania Said Anwar Amer, Department of Clinical Pathology, Tanta University, Tanta, Gharbi Governorate, Egypt.

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    Author:

    Rania Said Anwar Amer1 *, Morad Ahmed Morad1 , Gihan Farouk Attia1 , Nesreen Ahmed Kotb2

    Title:Role of toll-like receptor 4 +3725 G/C polymorphism in type 2 diabetes mellitus
    Journal:Drug Invention Today
    Vol(issue):11 (March)
    Year:2019
    Page No: (548-552)
  • Experimental Methods Keywords

    Methodology:Prospective case–controlled study, Type 2 diabetes mellitus
    Research Materials:75 patients with type 2 diabetes

Keywords

Polymorphisms Toll-like receptor 4 Type 2 diabetes mellitus

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