Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-AC-0000321
Title: Physicochemical characterization, formulation, and dissolution studies of ezetimibe hydroxypropyl ß -cyclodextrin inclusion complex.
Category: Analytical Chemistry
Section: Research Article
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    The objective of this research was to prepare, characterize and to study effect on dissolution of inclusion complexes of Ezetimibe (EZM), with hydroxypropyl- ß- cyclodextrin (HPß-CD). Phase solubility curve was of A L type, indicating the 1:1 stoichimetry for HP-ß-CD: EZM complexation. The complexes were prepared by methods such as kneading, co-evaporation and physical mixing. The EZM in all samples were characterized by FTIR spectroscopy, DSC and PXRD studies. The highest improvement indissolution of EZM was observed in complex prepared using co-evaporation method and were assessed by mean dissolution time (MDT) and similarity factor f2.

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    Author(s) Name:

    Kane R.N. *1 , Kuchekar B.S. ,Naik S.R , Bumrela S.B.

    Affiliation(s) Name:

    *1 Sinhgad Institute of Pharmaceutical Sciences, S. No. 809/810, off Mumbai-Pune Expressway,Kusgaon (Bk.), Lonavala Dist. Pune. 410 401Maharashtra, India.
    B.S. Kuchekar. M.I.T. College of Pharmacy, Erandavane, Pune. Maharashtra, India

    *Corresponding author.
    Kane R. N.
    Sinhgad Institute of Pharmaceutical Sciences,
    S. No. 809/810, off Mumbai-Pune Expressway,
    Kusgaon (Bk.), Lonavala Dist. Pune. 410 401
    Maharashtra, India.
    Received on: 28-10-2009; Revised on: 16-12-2009; Accepted on:13-01-2010

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    Author:

    Kane R.N. *1 , Kuchekar B.S. ,Naik S.R , Bumrela S.B.

    Title:Physicochemical characterization, formulation, and dissolution studies of ezetimibe hydroxypropyl ß -cyclodextrin inclusion complex.
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):1 (February)
    Year:2010
    Page No: (22-27)
  • Experimental Methods Keywords

    Methodology:in-vitro dissolution studies, inclusion complex
    Research Materials:ezetimibe hydroxypropylß -cyclodextrin

Keywords

Ezetimibe hydroxypropyl-ß-cyclodextrin in-vitro dissolution studies inclusion complex.

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