Journal: Drug Invention Today

Article Id: JPRS-P col-00003224
Title: Knowledge on Rebamipide a novel agent used for the treatment of recurrent aphthous ulcer - A Review
Category: Pharmaceutics
Section: Review Article
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    Aim: The aim of this review paper is to assess the efficacy of rebamipide in the treatment of recurrent aphthous ulcer (RAU). Objective: The purpose of this review is to evaluate the use, mechanism of action, dosage, and adverse effects of rebamipide. Background: Recurrent aphthous stomatitis (RAS) or RAU, frequently referred to as “canker” sores, is among the most common oral condition. The classic presentation of RAS is recurrent, self-limiting ulcers that mainly affect non-keratinized oral mucosa. The etiology appears to be multifactorial with numerous causative and precipitating factors. The primary goals of therapy of RAS are relief of pain, reduction of ulcer duration, and the restoration of normal oral function. Rebamipide 2-(4-chlorobenzoylamine)-3-[2-(1H)-quinolinon-4-yl] is a new mucoprotective agent which enhances preservation of existing epithelial cells and replacement of lost tissue through stimulation of PGs release and inhibition of free radicals and might also be useful in preventing and treating frequently recurrent oral aphthous ulcers. Clinical and experimental data indicate that rebamipide accelerates ulcer healing, improves scar quality and prevents ulcer recurrence. Several electronic databases were searched and potentially relevant articles were taken for literature review about rebamipide. Conclusion: RAS is one of the common clinical oral diseases that produce painful ulcerations in the oral cavity. The available treatments still remain unsatisfactory with the ability to reduce the severity, healing time, and the frequency of recurrence of ulceration with no permanent and definitive treatment. This review is done to provide a review on the recent treatment modality which may give the clinician broad and detailed picture to deal with RAS in an appropriate way.

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    Author(s) Name:

    Sanjay Madhavan1 , Mebin George Mathew2 *

    Affiliation(s) Name:

    1 Department of Pedodontics and Preventive Dentistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Pediatric and Preventive Dentistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai,Tamil Nadu, India

    *Corresponding author: Dr. Mebin George Mathew, Department of Pediatric and Preventive Dentistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

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    Author:

    Sanjay Madhavan1 , Mebin George Mathew2 *

    Title:Knowledge on Rebamipide a novel agent used for the treatment of recurrent aphthous ulcer - A Review
    Journal:Drug Invention Today
    Vol(issue):11 (March)
    Year:2019
    Page No: (624-629)
  • Experimental Methods Keywords

    Methodology:Recurrent aphthous stomatitis (RAS)
    Research Materials:Rebamipide

Keywords

Aphthous Rebamipide Stomatitis Treatment

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