Journal: Drug Invention Today

Article Id: JPRS-P col-00003230
Title: Analgesic efficacy and safety of transdermal and oral diclofenac in postoperative pain management following periodontal flap surgery
Category: Pharmaceutics
Section: Research Article
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    Introduction: The scope of transdermal analgesics has been limited to pain control following local trauma, muscle spasms, and sports-related injuries. Its the scope of application can be extended in the field of dentistry and minor oral surgical procedures. The aim of this study was to compare the effectiveness and safety of transdermal and oral routes of diclofenac for post-operative management in patients undergoing periodontal flap surgery. Materials and Methods: A total of 15 systemically healthy patients between the age of 30 and 60 years who were diagnosed with generalized chronic periodontitis based on AAP 1999 classification for whom flap surgery required in at least two quadrants were taken for the study. Group A: For the flap surgery on the first quadrant 50 mg of oral diclofenac was prescribed twice daily for 3 days, Group B: For the contralateral side flap surgery, the patients were prescribed with transdermal patch of diclofenac diethylamine 100 mg and patients were asked to replace it every 24 h for 3 days, and the pain intensity was assessed using a numeric rating scale and data collected on the 3rd day of review were tabulated, and the significance in the pain intensity was statistically analyzed using Mann–Whitney U-test in SPSS software 23.0 version. Results: There was significantly lower pain intensity at 2, 4, 8, and 12 h when the patient used oral diclofenac sodium compared to the transdermal patch of diclofenac diethylamine. There was no significant difference in the pain intensity at 24, 48, and 72 h when the patient used either oral diclofenac or the transdermal patch of diclofenac. Conclusion: Pain intensity was significantly lower in oral diclofenac group when compared to transdermal diclofenac after periodontal flap surgery. It is better to advise oral diclofenac for the 1st day postoperatively followed by transdermal patches can be administered for the next 2 days so that it can avoid the gastric irritation caused by oral administration of diclofenac; further studies are required to confirm the results and safety for its use in various other dental situations.

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    Author(s) Name:

    Karthikeyan Murthykumar, Sheeja Varghese

    Affiliation(s) Name:

    Department of Periodontics, Saveetha Dental College, Chennai, Tamil Nadu, India

    *Corresponding author: Sheeja Varghese, Department of Periodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, No 162, Poonamallee High Road, Chennai - 600 077, Tamil Nadu, India

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    Karthikeyan Murthykumar, Sheeja Varghese

    Title:Analgesic efficacy and safety of transdermal and oral diclofenac in postoperative pain management following periodontal flap surgery
    Journal:Drug Invention Today
    Vol(issue):11 (March)
    Page No: (652-656)
  • Experimental Methods Keywords

    Methodology: Chronic periodontitis, Pain control, Periodontal flap surgery, Transdermal patch
    Research Materials:Diclofenac,


Chronic periodontitis Diclofenac Pain control Periodontal flap surgery Transdermal patch

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