Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-AC-0000324
Title: RP-HPLC method development for the determination of assay of Donepezil hydrochloride
Category: Analytical Chemistry
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    RP-HPLC method was developed and validated by assessing linearity, accuracy, selectivity, limit of quantitation, and precision for the determination of Donepezil hydrochloride. Donepezil was identified and quantitated on a C18 reversed phase column (3.9×150mm, 5.0μm), using a mobile phase composed of acetate buffer-Acetonitrile (50:50v/v) delivered at a flow rate of 1.0mL/min, and with UV detection (λexcitation = 230nm). The method was proven to be linear over a Donepezil hydrochloride concentration range of 12.5 to 75μg/mL with a mean correlation coefficient of 0.9999.

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    Useni Reddy Mallu1 K. Hussain Reddy1, Varaprasad Bobbarala2*, Somasekhar Penumajji3,

    Affiliation(s) Name:

    1Department of Chemistry, Sri Krishnadevaraya University, Anathapur-515003, A.P. India
    *2Department of Botany, Andhra University, Visakhapatnam-530003, A.P. India.
    3Vivimed labs Limited, 2nd, 4th Floor, Veeranag towers, Habsiguda, Hyderabad, A.P. India

    *Corresponding author.
    Dr. Varaprasad Bobbarala M.Sc., Ph.D.
    # 36-92-248/23, Sreenivasa Nagar,
    Kancharapalem, Visakhapatnam-530008,
    Andhrapradesh, India.


    Received on: 20-11-2009; Revised on: 16-12-2009; Accepted on:17-02-2010

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Useni Reddy Mallu1 K. Hussain Reddy1, Varaprasad Bobbarala2*, Somasekhar Penumajji3,

    Title:RP-HPLC method development for the determination of assay of Donepezil hydrochloride
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):1 (February)
    Year:2010
    Page No: (35-36)
  • Experimental Methods Keywords

    Methodology:RP-HPLC method
    Research Materials:Donepezil hydrochloride

Keywords

Donepezil hydrochloride high performance liquid chromatography (HPLC) Acetonitrile UV detection.

Our Services

Most Downloaded List