Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-AC-0000338
Title: New Spectrophotometric method to determine Ketoprofen in tablet dosage form using mixed Hydrotropy
Category: Analytical Chemistry
Section: Research Article
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  • Abstract

    In this investigation, a blend consisting of 30% urea and 30% sodium citrate solution has been used as hydrotropic solubilizing agent for ketoprofen to carry out its spectrophotometric analysis. Ketoprofen shows tremendous increase in aqueous solubility of more than 700 folds in this blend. Thus, it was thought worthwhile to solubilize ketoprofen by this blend of solubilizing agents to carry out spectrophotometric analysis. Ketoprofen showed maximum absorbance at 260 nm and Beer’s law was obeyed in concentration range of 4-20 μg/ml. The mean percent label claims estimated were very close to 100 with low values of standard deviation, percent coefficient of variation and standard error indicating the accuracy of the proposed analytical method. The results of recovery studies showed that the mean percent recoveries ranged from 99.49 to 101.37, which further proved the validity and reproducibility of the proposed method. Thus, it may be concluded that the proposed method of analysis is new, simple, cost-effective, environmentally friendly, safe, accurate, and reproducible.

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    Author(s) Name:

    Maheshwari R.K.*, Rathore Amit and Agrawal Archana

    Affiliation(s) Name:

    Department of Pharmacy, S.G.S.I.T.S., 23, Park Road,Indore – 452 003

    *Corresponding author.
    Dr. R.K.Maheshwari,
    Department of Pharmacy, S.G.S.I.T.S.,
    23, Park Road,Indore – 452 003


    Received on: 16-12-2009; Revised on: 16-01-2010; Accepted on:08-03-2010

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    Author:

    Maheshwari R.K.*, Rathore Amit and Agrawal Archana

    Title:New Spectrophotometric method to determine Ketoprofen in tablet dosage form using mixed Hydrotropy
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):1 (April)
    Year:2010
    Page No: (62-63)
  • Experimental Methods Keywords

    Methodology:spectrophotometric analysis, mixed hydrotropy,
    Research Materials:Ketoprofen

Keywords

Ketoprofen mixed hydrotropy spectrophotometric analysis environmentally friendly.

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