Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-AC-0000339
Title: Photodegradation and Photostabilization of Ascorbic Acid in Pharmaceutical Preparations
Category: Analytical Chemistry
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    A number of drug substances and their formulated products including ascorbic acid may degrade on exposure to light and appropriate precautions are to be taken to preserve the active ingredients as raw material and in dosage forms. Ascorbic acid solutions on UV irradiation are degraded to dehydroascorbic acid and further photoproducts including 2,3-diketo-L-gulonic acid, oxalic acid and L-theoronic acid. Pharmaceutical formulations containing ascorbic acid have been stabilized by using antioxidants, DL-methionine, mannitol, sorbitol, sucrose, dextrose, halide salts, triplet quenchers, metal-complexing agents and viscosity enhancing agents.

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    Muhammad Ali Sheraz,a* Sofia Ahmed,a Iqbal Ahmad,a Kiran Qadeera and Faiyaz H.M. Vaidb.

    Affiliation(s) Name:

    a Institute of Pharmaceutical Sciences, Baqai Medical University, Toll Plaza, Super Highway, Gadap Road, Karachi-74600. Pakistan.
    b Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan.

    *Corresponding author.
    Muhammad Ali Sheraz
    Institute of Pharmaceutical Sciences,
    Baqai Medical University,
    Toll Plaza, Super Highway,
    Gadap Road, Karachi-74600. Pakistan.


    Received on: 05-11-2009; Revised on:03-01-2010; Accepted on:04-03-2010

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    2 View More
  • How to Cite my Article.

    Author:

    Muhammad Ali Sheraz,a* Sofia Ahmed,a Iqbal Ahmad,a Kiran Qadeera and Faiyaz H.M. Vaidb.

    Title:Photodegradation and Photostabilization of Ascorbic Acid in Pharmaceutical Preparations
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):1 (April)
    Year:2010
    Page No: (68-70)
  • Experimental Methods Keywords

    Methodology:Photodegradation and Photostabilization
    Research Materials:Ascorbic Acid

Keywords

Ascorbic acid dehydroascorbic acid photodegradation photostabilization UV effects

Our Services

Most Downloaded List