Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-000034
Title: Development and validation of a stability indicating UV spectrophotometric method for the estimation of losartan potassium in bulk and tablet dosage form
Category: Pharmaceutics
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  • Abstract

    A simple, sensitive and reproducible stability indicating UV Spectrophotometric method has been developed for quantitative determination of Losartan Potassium in bulk and pharmaceutical formulations. The UV- spectrum was scanned between 220 to 400 nm and 227.4 nm was selected as maximum wavelength for absorption. Beer’s law was obeyed in the concentration range of 2.02-22.22 mg/ml. Good accuracy (98.11-99.85%), precision (RSD 0.303-0.334) and selectivity (= 0.5%) were found, and the method was successfully applied to the pharmaceutical dosage form containing the above-mentioned drug without any interference by the excipients. The method was fast and economical and it was also selective and sensitive for the desirable range. Results of the analysis were validated as per ICH guidelines and by recovery studies. Stability testing study includes the effect of temperature, oxidation, photolysis and susceptibility to hydrolysis across a wide range of pH values.

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    Author(s) Name:

    Permender Rathee*1, Sushila Rathee1, Hema Chaudhary1 & Dharmender Rathee2

    Affiliation(s) Name:

    1PDM College of Pharmacy, Sarai Aurangabad, Bahadurgarh-124507, (Haryana) India
    2NIPER, Ahmedabad, Gujarat, India

     

    For correspondence:

    Permender Rathee,PDM College of Pharmacy, Sarai Aurangabad, Bahadurgarh-124507, (Haryana) India


    E-mail: rathee_permender@rediffmail.com


    Received on: 13-05-2008; Accepted on :08-08-2008

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    Author:

    Permender Rathee*1, Sushila Rathee1, Hema Chaudhary1 & Dharmender Rathee2

    Title:Development and validation of a stability indicating UV spectrophotometric method for the estimation of losartan potassium in bulk and tablet dosage form
    Journal:Journal of Pharmacy Research
    Vol(issue):1(2)
    Year:2008
    Page No: (188-192)
  • Experimental Methods Keywords

    Methodology:Spectrophotometry
    Research Materials:Losartan Potassium

Keywords

Spectrophotometry Losartan Potassium Stability Indicating Validation

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