Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-AC-0000341
Title: Simultaneous estimation of sumatriptan succinate and ergotamine tartrate in the tablet dosage form.
Category: Analytical Chemistry
Section: Research Article
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  • Abstract

    A simple, specific, accurate and economical, an isocratic reversed phase liquid chromatographic (RP-HPLC) method was developed and subsequently validated for the determination of sumatriptan succinate and ergotamine tartrate. Separation was achieved with a Nucleodur C– 18 column having 250x4.6 mm i.d. with 5μm particle size and 10mmol disodium hydrogen phosphate buffer, adjusted to pH 6.5 using diluted ortho phosphoric acid and acetonitrile (50:50 v/v) with isocratic program as eluent at a constant flow rate of 1.0 ml/min. UV detection was performed at 210 nm. The retention times of sumatriptan succinate and ergotamine tartrate were about 3.79min and 8.00min respectively. This method is simple, rapid and selective and can be used for routine analysis of sumatriptan succinate and ergotamine tartrate. The proposed method shows good linearity, accuracy and reproducibility. Results of analysis validated statistically and by recovery studies.

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  • About the authors and Affiliations

    Author(s) Name:

    Freddy H. Havaldar* and Dharmendra L.Vairal

    Affiliation(s) Name:

    Nadkarny-Sacasa Research Laboratory, Department Of Chemistry,St. Xavier’s College, Mumbai – 400 001, India.

    *Corresponding author.
    Freddy H. Havaldar
    Nadkarny-Sacasa Research Laboratory, Department Of
    Chemistry,St. Xavier’s College, Mumbai – 400 001, India.


    Received on: 12-11-2009; Revised on: 16-02-2010; Accepted on:07-03-2010

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    Author:

    Freddy H. Havaldar* and Dharmendra L.Vairal

    Title:Simultaneous estimation of sumatriptan succinate and ergotamine tartrate in the tablet dosage form.
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):1 (April)
    Year:2010
    Page No: (76-78)
  • Experimental Methods Keywords

    Methodology:RP-HPLC
    Research Materials:Sumatriptan succinate (SUMA), Ergotamine tartrate (ERGO)

Keywords

Sumatriptan succinate (SUMA) Ergotamine tartrate (ERGO) and RP-HPLC.

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