Journal: Drug Invention Today

Article Id: JPRS-P col-00003432
Title: Lupeol normalizes high-fat diet-induced alternations in the Akt levels in the quadriceps muscle of type 2 diabetic rats
Category: Pharmaceutics
Section: Research Article
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    Background: Lupeol is a pharmacologically active triterpenoid found in mango and also in variety of medicinal plants including Acacia visco and Abronia villosa. It is also found in dandelion coffee. Many scientific studies have shown that lupeol possesses many beneficial pharmacological activities including anti-inflammatory, antioxidant, and antihyperglycemic activity. Biomarkers for oxidative damage to DNA, lipids, and proteins are also supporting the concept of increased oxidative stress in diabetes and diabetic nephropathy. In the present study, we elucidated the antioxidant potential of lupeol by analyzing the enzymic and non-enzymic antioxidant in the liver of high-fat diet- and sucrose-induced Type-2 diabetic rats. Objectives: The study aimed to identify the effects of lupeol on Akt and its phosphorylation in the quadriceps muscle of high-fat diet- and sucrose-induced Type-2 diabetic adult male rats. Materials and Methods: Lupeol was administered orally to Type-2 diabetic rats (25 mg/kg body weight) for a period of 30 days. After the treatment period, animals were anesthetized and liver from control and experimental rats dissected out and the used for the studied. Results: There was a marked decrease observed in the levels of Akt and its phosphorylation (p-Akt Ser473 ) in the quadriceps muscle of the type-2 diabetic rats. However, lupeol treatment efficiently increased the level of Akt protein compared to diabetic group. Metformin showed a similar pattern to that of lupeol. Conclusion: The present finding concludes that the lupeol regulates insulin-mediated Akt signaling in gracilis muscle. Therefore, the plant-derived triterpenoid may be used as antidiabetic phytocompound for the type-2 diabetic management.

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    Author(s) Name:

    K. Nirubama, V. Vishnu Priya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi, J. Selvaraj1 *

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India,

    2 Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, India

    *Corresponding author: Dr. J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences,Chennai - 600 077, Tamil Nadu, India.

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    Author:

    K. Nirubama, V. Vishnu Priya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi, J. Selvaraj1 *

    Title:Lupeol normalizes high-fat diet-induced alternations in the Akt levels in the quadriceps muscle of type 2 diabetic rats
    Journal:Drug Invention Today
    Vol(issue):12 (April)
    Year:2019
    Page No: (794-797)
  • Experimental Methods Keywords

    Methodology: Akt, High fat and high sucrose,p-Akt, Type-2 diabetes
    Research Materials: Lupeol

Keywords

Akt High fat and high sucrose Lupeol p-Akt Type-2 diabetes

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