Journal: Drug Invention Today

Article Id: JPRS-P col-00003433
Title: Hepatoprotective effect of lupeol is mediated through gluconeogenic enzymes: An experimental study
Category: Pharmaceutics
Section: Research Article
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    Aim: This study aims to the aspect of lupeol on gluconeogenic enzymes such as fructose-1,6-bisphosphatase and glucose-6- phosphatase in the liver of type-2 diabetic male rats. Experimental Design: In the present study, healthy adult male albino rats were used and divided four groups each consisting of six animals. The oral effective dose of lupeol (2 , orally for 30 days) was administrated to high-fat diet-I plus type 2 diabetic rats. At the end of the experimental period, liver tissues from the control and experimental group were dissected out and used for the assessment of gluconeogenic enzymes (glucose-6-phosphate, fructose-1, 6-bisphosphate, and phosphoenolpyruvate carboxykinase using standard method of spectrophotometric analysis, the data will be subjected to one-way analysis of variance using computer-based software (GraphPad Prism, resin 5). The significance will be considered at the level of P < 0.05. Results: Diabetic rats showed a significant increase in the levels of gluconeogenic enzymes such as fructose-1,6-bisphosphatase and glucose-6-phosphatase in the liver. However, lupeol administration to type-2 diabetic rats significantly reduced the altered levels of the enzymes equal to that of the standard drug metformin. Conclusion: It is concluded from the present findings that lupeol regulates glucose homeostasis in liver through the controlling of the gluconeogenic enzymes as a result of increase in the insulin sensitivity, and hence, lupeol has protective role in hepatocytes.

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    Author(s) Name:

    M. Gajapriya1 , J. Selvaraj 1 *, V. Vishnu Priya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    M. Gajapriya1 , J. Selvaraj 1 *, V. Vishnu Priya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1

    Title:Hepatoprotective effect of lupeol is mediated through gluconeogenic enzymes: An experimental study
    Journal:Drug Invention Today
    Vol(issue):12 (April)
    Year:2019
    Page No: (798-800)
  • Experimental Methods Keywords

    Methodology:Gluconeogenic enzymes, High-fat diet, Liver,
    Research Materials:Lupeol

Keywords

Gluconeogenic enzymes High-fat diet Liver Lupeol

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