Journal: Drug Invention Today

Article Id: JPRS-P col-00003440
Title: In vitro cytotoxicity studies of silver nanoparticles with activated folic acid on cancer cell lines
Category: Pharmaceutics
Section: Research Article
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    Introduction: Folate is a water-soluble vitamin that appears to play an important role in the pathogenesis of several disorders in humans. The expanding role of folate nutrition in health and disease has major public health implications. Nanotechnology offers a wealth of tools to treat cancer bypassing biological barriers to deliver therapeutic agents directly. In this study, the anticancer activity of AgNPs with activated FA was studied against KB oral cancer cell lines. Materials and Methods: The FA modified silver NPs (AgNPs) were obtained by chemical activation. Procured KB cells were cultured in Roswell Park Memorial Institute 1640 culture medium, with 10% fetal bovine serum (FBS), L–glutamine, 1% penicillin (100 U/ml), and streptomycin (100 μg/ml) at 37°C in a humidified CO2 (5%) chamber and 95% air. The cytotocity assay was performed using standard protocol and compared with the standard drug. Results: The effect of test samples on cell growth inhibition was assessed as percent cell viability, where vehicle-treated cells were taken as 100% viable. There was a decrease in the percentage of cell viability with the increase in the concentration of FA-AgNps (0.2–1.0 mmole/L). Conclusion: As the concentration of the test sample was increased, the KB cells showed a significant decrease in cell viability.

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    Author(s) Name:

    Charanya Suresh1 , R. Gayathri 2 *, V. Vishnu Priya2

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: R. Gayathri, Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 160, Poonamallee High Road, Chennai – 600 077, Tamil Nadu, India.

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    Author:

    Charanya Suresh1 , R. Gayathri 2 *, V. Vishnu Priya2

    Title:In vitro cytotoxicity studies of silver nanoparticles with activated folic acid on cancer cell lines
    Journal:Drug Invention Today
    Vol(issue):12 (April)
    Year:2019
    Page No: (823-825)
  • Experimental Methods Keywords

    Methodology:Activated folic acid, Cancer cell lines, Silver nanoparticles
    Research Materials:Folic acid

Keywords

Activated folic acid Cancer cell lines Silver nanoparticles

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