Journal: Drug Invention Today

Article Id: JPRS-P col-00003475
Title: Neutrophil gelatinase-associated lipocalin – A novel biomarker for mercury-induced nephrotoxicity
Category: Pharmaceutics
Section: Research Article
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    Introduction: The metal which has a relatively high density and toxic at low quantity is referred as heavy metals. The common heavy metals are arsenic, lead, mercury, cadmium, chromium, and thallium. Aim and Objective: The aim of this study was to analyze the mercuric chloride toxicity in the kidneys of Wistar albino rats. Materials and Methods: Female Wistar rats with an average weight of 180 ± 20 g and age of 120–140 days were assimilated for a week. Mercuric chloride (5 mg/kg b.w) and normal physiological saline (2 ml/kg/b.w) were administrated through intraperitoneal and oral route, respectively, for 5 days. Collection of blood and tissue was done to investigate serum biomarkers and histopathology for nephrotoxicity. Results: A significant change was observed in the levels of serum urea, creatinine, and neutrophil gelatinase- associated lipocalin (NGAL) and atypical changes such as tubular necrosis and atrophy of renal tissues. NGAL is a reliable novel biomarker for identifying the mercuric chloride-induced nephrotoxicity in rats.

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    Author(s) Name:

    Yuvaraj Maria Francis1 *, J. Vijayakumar1 , Senthilkumar Sivanesan2 , Ethirajan Sukumar2 , R. Vijayaraghavan2 , Madhankumar Swaminathan2 , P. Praveen Kumar2

    Affiliation(s) Name:

    1 Department of Anatomy, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India,

    2 Department of Research and Development, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India

    *Corresponding author: Yuvaraj Maria Francis, Department of Anatomy, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamil Nadu, India.

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    Author:

    Yuvaraj Maria Francis1 *, J. Vijayakumar1 , Senthilkumar Sivanesan2 , Ethirajan Sukumar2 , R. Vijayaraghavan2 , Madhankumar Swaminathan2 , P. Praveen Kumar2

    Title:Neutrophil gelatinase-associated lipocalin – A novel biomarker for mercury-induced nephrotoxicity
    Journal:Drug Invention Today
    Vol(issue):11 (May)
    Year:2019
    Page No: (1134-1137)
  • Experimental Methods Keywords

    Methodology:Nephrotoxicity, Neutrophil gelatinase-associated lipocalin, Serum creatinine
    Research Materials: Biomarkers

Keywords

Biomarkers Mercuric chloride Nephrotoxicity Neutrophil gelatinase-associated lipocalin Serum creatinine

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