Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-SDS-0000349
Title: Pharmacological action and SAR of Phthalazine derivatives - A Review
Category: Synthetic Drug Study
Section: Review Article
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    The chemistry of phthalazine (2, 3 benzodiazine) is very well known. These systems are widely used in organic chemistry as intermediates for the synthesis of numerous compounds. On the other hand; phthalazine derivatives were extensively studied as bioactive compounds. They possess remarkable biological activity, such as anticonvulsant, antimicrobial, anti-inflammatory, antifungal, antibacterial and vasorelaxant activity among others. Recently, the research and development in the medicinal chemistry of phthalazine produced hybrid compounds in which phthalazine moiety together with classical drug moieties are present in a single molecule. So, new anticonvulsant drugs, PDE4 inhibitor and Topoisomerase II inhibitors were developed. These review paper recent developments in the medicinal chemistry of phthalazine will be reviewed.

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    Author(s) Name:

    Smita Singh1*, Ajay Yadav1, A K Meena2, Uttam Singh1, B Singh1, A Gaurav1, M M Rao2, P Panda2 and R Singh1.

    Affiliation(s) Name:

    1 School of pharmaceutical sciences, Shobhit University, Meerut, UP, ,India
    2 National Institute of Ayurvedic Pharmaceutical Research, Patiala – 147001, Punjab,India

     

    *Corresponding author.
    Smita Singh,
    School of Pharmaceutical Sciences,
    Shobhit University, Meerut.

    Received on: 04-01-2010; Revised on: 08-02-2010; Accepted on:12-04-2010

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    Author:

    Smita Singh1*, Ajay Yadav1, A K Meena2, Uttam Singh1, B Singh1, A Gaurav1, M M Rao2, P Panda2 and R Singh1.

    Title:Pharmacological action and SAR of Phthalazine derivatives - A Review
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):1 (May)
    Year:2010
    Page No: (79-87)
  • Experimental Methods Keywords

    Methodology:Pharmacological action and SAR
    Research Materials:Phthalazine derivatives

Keywords

MES test activity PDE4 activity Anticonvulsant activity Vasorelaxant.

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