Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-000035
Title: Formulation and evaluation of buccoadhesive tablets of Atenolol
Category: Pharmaceutics
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  • Abstract

    The aim of the study was to prepare and characterize buccoadhesive tablets of atenolol using different mucoadhesive polymers such as carbopol 934P, sodium alginate and hydroxypropyl methylcellulose K100M in combination. The bilayered buccoadhesive tablets were prepared by direct compression technology. The prepared tablets were evaluated for physicochemical parameters such as hardness, thickness uniformity, weight variation, surface pH and swelling studies. Also prepared tablets were evaluated for bioadhesive strength and in vitro drug release. In vitro bioadhesive strength studies showed that formulations containing combination of carbopol 934P and hydroxypropyl methylcellulose were more bioadhesive than sodium alginate. In vitro dissolution studies revealed that all the formulations exhibited non-fickian release kinetics. The optimized formulations F4 and F10 showed 90% release in 8 hr in vitro dissolution studies.

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    Author(s) Name:

    Prasad B Kadam*1, Remeth J Dias1, Kailas K Mali1, Vijay D Havaldar1 and Niranjan S Mahajan1

    Affiliation(s) Name:

    1Department of Pharmaceutics, Satara College of Pharmacy, Satara, Maharashtra, 415004 


    For correspondence:

    Prasad B Kadam, Satara College of Pharmacy,Plot No. 1539, Behind Spicer IND Ltd.,New Add MIDC, Degaon, Satara, Maharashtra, 415004. 


    E-mail: vdh2006@rediffmail.com 


    Received on:05-05-2008; Accepted on :22-09-2008

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    Author:

    Prasad B Kadam*1, Remeth J Dias1, Kailas K Mali1, Vijay D Havaldar1 and Niranjan S Mahajan1

    Title:Formulation and evaluation of buccoadhesive tablets of Atenolol
    Journal:Journal of Pharmacy Research
    Vol(issue):1(2)
    Year:2008
    Page No: (193-199)
  • Experimental Methods Keywords

    Methodology:Formulation and evaluation
    Research Materials:Buccoadhesive tablets of Atenolol

Keywords

Atenolol carbopol 934P sodium alginate

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